Objective To establish an expert consensus on the management of low anterior resection syndrome (LARS) in patients with rectal cancer post-surgery(hereinafter referred to as “consensus”),aiming to standardize the related work of medical institutions in the context of post-operative LARS. Methods A comprehensive search of domestic and international databases was conducted to collect guidelines,expert consensuses,systematic reviews,evidence summaries,and original research related to post-operative LARS in rectal cancer published from the establishment of the databases until August 2024. Based on clinical practice experience,a preliminary draft of the “consensus” was formed. From September to November 2024,22 experts were invited to participate in 2 rounds of expert consultations,during which the draft content was revised and improved,and the final version of the “consensus” was determined through expert validation. Results A total of 22 experts responded,achieving a response rate of 100%. The effective recovery rate of the consultation questionnaires in both rounds was 100%,with an expert authority coefficient of 0.89,a judgment coefficient of 0.97,and a familiarity degree of 0.84. The Kendall harmony coefficients for the 2 rounds of expert consultations were 0.122 and 0.136,respectively(P<0.001). This consensus covers 5 main aspects:definition,assessment,prevention,treatment,and follow-up management of LARS. Conclusion This consensus demonstrates a high level of scientific rigor and can provide a strong reference for clinical nursing personnel in the specialized care of rectal cancer patients with post-operative LARS.