Objective To develop a perioperative proactive health behavior intervention program for colorectal cancer patients undergoing ostomy surgery and verify its preliminary application effects.Methods The program was formulated through literature review,qualitative interviews,and Delphi expert consultations. The intervention program comprised 3 first-level,9 second-level,and 27 third-level indicators. Patients hospitalized for colorectal cancer undergoing ostomy surgery at a tertiary hospital in Anhui Province between January and November 2025 were recruited as study participants. Using the drawing lots method,patients were randomized by ward into groups:33 patients from Ward A were assigned to an experimental group,and 33 from Ward B to a control group. The control group received routine care,while the experimental group received the intervention program in addition to routine care. The application effects were then evaluated.Results A total of 32 cases in the experimental group and 31 cases in the control group completed the study. Preliminary application results showed a significant difference in ostomy complication rates between the 2 groups at 1 and 3 months post-intervention(P<0.05),and the incidence in the experimental group was lower than that in the control group. Repeated measures ANOVA showed that there was a time and group interaction effect on self-management ability,self-efficacy,health promoting behavior level,and quality of life between the 2 groups of patients(P<0.05). Simple effects analysis showed that at 1 and 3 months after intervention,the experimental group had significantly higher scores in self-management ability,self-efficacy,health promoting behavior level,and quality of life than the control group(P<0.001).Conclusion The implementation of this program can effectively enhance self-management ability,self-efficacy,and health-promoting behavior levels in colorectal cancer patients undergoing ostomy surgery,thereby improving their quality of life.