Objective To construct an intervention program for social alienation in patients with enterostomy,and preliminarily verify the clinical feasibility of this program in reducing social alienation in enterostomy patients. It is expected to provide a reference for clinical nursing to promote the development of healthy behaviors in patients. Methods From December 2023 to November 2024,based on the theory of planned behavior and nudge strategies,an intervention program for social alienation in patients with enterostomy was constructed through mixed-methods research,literature research,expert meetings. Patients with enterostomy who attended the Department of Gastrointestinal Surgery and Stoma Clinic of a tertiary A hospital in Luzhou from August to October 2024 were selected as research subjects using the convenient sampling method. They were divided into an intervention group and a control group by time stratification. The control group received routine health education of the department,while the intervention group received the intervention program revised by expert meetings. The levels of social alienation,self-esteem,and self-concealment of patients in both groups were evaluated before the intervention and 4 weeks after the intervention,respectively. Results A total of 16 experts participated in the expert meeting,with a 100% valid questionnaire return rate and an expert authority coefficient of 0.86. 6 modification suggestions were proposed, leading to the development of an intervention program for social alienation in enterostomy patients,which included 5 intervention themes and 14 intervention measures. A total of 39 enterostomy patients were enrolled,and they were divided into an experimental group(20 cases) and a control group(19 cases). No statistically significant differences were found in the general data of both groups before the intervention(P>0.05). At 4 weeks after the intervention, the experimental group scored lower than the control group on all dimensions of social alienation and total score,while the experimental group had higher self-esteem scores and lower self-concealment scores than the control group, with statistically significant differences(P<0.05). Conclusion The intervention program can alleviate social alienation,enhance self-esteem,and reduce self-concealment tendencies in patients with enterostomy.