Objective To evaluate the effect of a self-management behavior intervention program based on positive or negative information framing in patients after pituitary adenoma surgery，aiming to improve specialized nursing care quality. Methods From January to April 2025，using convenience sampling，patients who underwent transsphenoidal pituitary adenoma resection in the neurosurgery department of a tertiary hospital in Zhengzhou were selected as study participants. They were randomly divided into 3 groups using a random number table，with 28 patients in each group. The experimental groups received a self-management behavior intervention based on information framing effects（the positive group received interventions based on positive information frames, while the negative group received interventions based on negative information frames），while the control group received routine postoperative health education. Differences in chronic disease self-management levels，patient activation，and quality of life among the 3 groups were compared before and after the intervention. Results A total of 80 patients completed the study （27 in the positive framing group，27 in the negative framing group，and 26 in the control group）. The negative framing group showed significantly better self-management levels than both the positive framing group and the control group （both P<0.001）. Patient activation was also higher in the negative framing group compared to the other 2 groups （both P<0.05）. Regarding quality of life，the experimental groups scored better in “future uncertainty” than the control group （H=9.676，P=0.008），and the negative framing group had better outcomes for“visual disorder”（both P<0.05）. Conclusion A negative information framing approach is more effective in enhancing self-management，patient activation，and visual outcomes post-surgery，offering a valuable strategy for optimizing rehabilitation.
