Objective To construct a “48-hour whole-process management” nursing model and explore its application effect for patients with total hip arthroplasty. Methods Based on the experience of literature retrieval and the actual process of the hospital,we set up a research team and constructed a “48-hour whole-process management” nursing model. Using the convenience sampling method,we selected 73 cases as the control group from January 2020 to May 2020,52 cases as the experimental group from June 2020 to March 2021 who performed total hip replacement surgery in the Department of Orthopedics and Arthritis of a tertiary hospital in Zhejiang Province. The experimental group adopts the “48-hour whole-process management” nursing mode,while the control group adopts the routine nursing mode. The differences in the total hospitalization cost,average hospitalization days,time of first eating after operation,time of first getting out of bed after operation,highest postoperative pain score,incidence of surgical complications,and incidence of 15-day readmission were compared between the experimental group and the control group. Results After the intervention,the average hospitalization cost(t=6.523,P<0.01),average length of stay(t=31.374,P<0.01),the time of first eating after operation(t=8.593,P<0.01),and the time of first getting out of bed after operation(t=19.620,P<0) in the experimental group were lower than those in the control group;there was no significant difference in the highest postoperative pain score between the 2 groups(t=0.276,P=0.783); the incidence of surgical complications and the incidence of 15-day readmission between the 2 groups are both 0. Conclusion The 48-hour whole-process management nursing mode of total hip replacement can accelerate the recovery of patients,shorten the hospitalization time,and reduce the hospitalization cost,while it does not increase the incidence of surgical complications and the 15-day readmission rate. It is a safe,feasible and scientific nursing management mode.