Objective To evaluate and summarize the relevant evidence of exercise intervention in peritoneal dialysis patients,so as to provide evidence-based bases for making the exercise guidance flow chart of peritoneal dialysis patients. According to the best evidence,the exercise guidance flow chart of peritoneal dialysis patients is made to facilitate clinical nurses to guide the exercise of peritoneal dialysis patients. Methods The computer search includes the World Health Organization,BMJ(best practice),the website of the National Institute for health and clinical optimization,the international guidelines collaboration network,the Scottish inter school guidelines website,the Joanna Briggs Institute(JBI),the U.S. national guidelines library,up to date,Embase,PubMed,Web of Science,Cochrane Library. Relevant literature on exercise of peritoneal dialysis patients in China biomedical literature database,Yimaitong,China knowledge network,Wanfang database and VIP database. The retrieval time is from the establishment of the database to November 1,2021. The quality of literature was evaluated and the evidence was extracted. The expert group meeting method was conducted to integrate the evidence and the flow chart of sports guidance was made. Results Finally,5 pieces of the literature were included,among which 4 were systematic reviews and 1 was expert consensus. The summary includes 8 aspects of exercise type,time,intensity,frequency,evaluation time,evaluation content,evaluation tools and precautions,22 pieces of best evidence,and the exercise guidance flow chart of peritoneal dialysis patients is made. Conclusion This study summarizes the best evidence related to exercise in peritoneal dialysis patients,and makes the exercise guidance process according to the best evidence,so as to provide references for clinical medical staff to guide exercise in peritoneal dialysis patients.