Abstract:

Objective To conduct a scoping review of studies on the use of virtual reality（VR） in cancer-related cognitive impairment（CRCI），and to generalize and summarize the current state of the art of VR use in CRCI. Methods The computerized retrieval of PubMed，Embase，Web of Science，the Cochrane Library，WanFang Data，CNKI and VIP databases was carried out. Studies were collected from the database establishment to July 2023. 3 researchers independently screened the literature，extracted data，and evaluated the risk of bias in the included studies. Results A total of 9 studies were included. VR was used for CRCI assessment and intervention. The assessment included visual and auditory memory，executive function and verbal fluency. The intervention content involved common cognitive impairment dimensions of CRCI，including memory，executive ability，attention，information processing speed and language fluency. The intervention frequency ranged from 3 to 5 times/week，15 to 60 min/time，and the duration was 2 to 8 weeks. The intervention frequency and intensity were dynamically adjusted based on the patient performance，game type and complexity. VR has shown good validity and benefits in CRCI assessments and interventions，while improving patients’ sleep quality and ability to perform daily living，with higher patient acceptance and no VR related adverse events being reported，but its role in improving mental health remains controversial. Conclusion VR shows good validity and benefits in CRCI assessment and intervention，and has good safety and high acceptance. In the future，it is still necessary to conduct large-sample，randomized controlled studies，attach importance to the role of patient needs in the formulation of VR cognitive intervention programs，and increase CRCI-related objective indicators to further verify the effect of VR intervention on CRCI. At the same time，longitudinal evaluation and follow-up programs may be considered to determine progressive changes in CRCI from VR interventions

Key words: Virtual Reality, Cancer-Related Cognitive Impairment, Nursing Care, Scoping Review

摘要：

目的 对虚拟现实（virtual reality，VR）技术在癌症相关认知障碍（cancer-related cognitive impairment，CRCI）患者中应用的研究进行范围审查，归纳和总结VR技术在CRCI患者中的应用现状。 方法 以澳大利亚乔安娜布里格斯研究所范围综述指南为方法学框架，检索PubMed、Embase、Web of Science、Cochrane Library、中国知网、万方数据知识服务平台、维普中文科技期刊数据库，时限为建库至2023年7月26日，对纳入文献进行汇总和分析。结果 共纳入9篇文献。评估内容包括视听觉记忆、执行功能和语言流畅性；干预内容涉及CRCI常见认知损伤维度，包括记忆力、执行力、注意力、信息处理速度和语言流畅性，干预频率多为3~5次/周，15~60 min/次，干预时间为2~8周，干预期间根据患者表现、游戏类型及复杂性，动态调整干预频率和强度。VR在CRCI的评估和干预中显示出较好的效度和益处，同时改善患者睡眠质量、提高日常生活能力，且未报告VR相关不良事件，患者接受度更高，但在改善心理健康方面尚存争议。 结论 VR技术在CRCI评估和干预中显示出较好的效果和益处，且安全性较好。未来仍需开展大样本量、随机对照研究，重视患者需求在VR技术认知干预方案制订中的作用，并增加CRCI相关客观指标，进一步验证VR技术对CRCI干预效果。同时，可考虑纵向评估和随访项目，以确定VR技术干预对CRCI的渐进性影响。

关键词: 虚拟现实, 癌症相关认知障碍, 护理, 范围综述