Nursing care for a patient with cytokine release syndrome following T-cell immunotherapy

doi:10.3761/j.issn.0254-1769.2025.09.016

Abstract

Abstract:

To summarize the nursing experience of a patient with relapsed/refractory diffuse large B-cell lymphoma who suffered from cytokine release syndrome after chimeric antigen receptor T-cell therapy. The main nursing experiences include：implementing emergency care for distributive shock caused by cytokine storm；carrying out the nursing of lung ventilation protection strategies；strengthening detailed skin care；prevention，control and care of hospital-acquired infections in an immunosuppressed state. After active treatment，the patient was transferred to the general ward 9 days later and discharged 27 days later.

Key words: Chimeric Antigen Receptor T Cells, Large B Cell Lymphoma, Cytokine Release Syndrome, Nursing Care

摘要：

总结1例复发难治性弥漫大B细胞淋巴瘤患者实施嵌合抗原受体T细胞治疗后合并细胞因子释放综合征的护理经验。护理要点：实施对细胞因子风暴导致的分布性休克的急救护理；积极落实肺通气保护策略；加强皮肤的细节护理；免疫抑制状态下，做好医院感染的防控与护理。经过积极地救治与护理，患者9 d后转入普通病房，27 d后出院。

关键词: 嵌合抗原受体T细胞, 大B细胞淋巴瘤, 细胞因子释放综合征, 护理

GU Qian, HUANG Xi, SHI Weixiong, WU Jing, TAN Ruoming, WANG Feng. Nursing care for a patient with cytokine release syndrome following T-cell immunotherapy[J]. Chinese Journal of Nursing, 2025, 60(9): 1124-1127.

谷茜, 黄玺, 施伟雄, 吴静, 谭若铭, 王枫. 1例T细胞免疫治疗后并发细胞因子释放综合征患者的护理[J]. 中华护理杂志, 2025, 60(9): 1124-1127.

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