Research progress on polypharmacy adherence management in HIV-infected people with chronic non-communicable diseases

doi:10.3761/j.issn.0254-1769.2022.14.019

Abstract

Abstract:

Due to the widespread use of AIDS antiretroviral drugs,the life expectancy of people infected with the human immunodeficiency virus（HIV） has been prolonged. The number of elderly people living with HIV has been increasing and eventually leading to the increase of HIV-infected people with chronic non-communicable diseases （NCDs） year by year. NCDs,including cardiovascular diseases,diabetes,cancer and chronic respiratory disease,require long-term use of multiple medications（polypharmacy） and complex antiretroviral drug regimens,which may lead to the reduced compliance of HIV-infected patients with medication,such as medication errors or missed medication. The problem of polypharmacy adherence of HIV-infected patients has gradually attracted people’s attention. This article systematically reviewed the related studies on the management of polypharmacy adherence in HIV-infected patients with NCDs,elaborated the definition and influencing factors of polypharmacy adherence,and proposed intervention measures to improve the polypharmacy adherence in HIV-infected patients with NCDs. This article aims to provide a reference for further research on adherence management and nursing practice of HIV-infected persons.

Key words: HIV Infections, Chronic Non-Communicable Diseases, Polypharmacy, Adherence, Nursing Care

摘要：

由于艾滋病抗病毒药物的广泛使用,HIV感染者寿命得以延长,老年HIV感染者的人数不断增多,最终导致HIV合并慢性非传染性疾病（chronic non-communicable diseases,NCDs）的人群逐年递增。NCDs包括心血管疾病、糖尿病、癌症和慢性呼吸道疾病等,需要长期服用多种药物,加之复杂的HIV抗病毒药物方案,会导致HIV感染者服药依从性降低,出现错服、漏服等现象。HIV感染者多药依从性问题逐渐引起重视。该文系统回顾了HIV感染者合并NCDs多药依从性管理的相关研究,对HIV感染者合并NCDs多药依从性的定义和影响因素进行阐述,并提出提高合并NCDs的HIV感染者多药依从性的干预措施,以期为HIV感染者多药依从性管理的研究和护理实践提供参考。

关键词: HIV感染, 慢性非传染性疾病, 多种药物疗法, 依从性, 护理

HE Jiamin, ZHU Zheng, LU Hongzhou. Research progress on polypharmacy adherence management in HIV-infected people with chronic non-communicable diseases[J]. Chinese Journal of Nursing, 2022, 57(14): 1788-1793.

何加敏, 朱政, 卢洪洲. HIV感染者合并慢性非传染性疾病多药依从性管理的研究进展[J]. 中华护理杂志, 2022, 57(14): 1788-1793.

References 41

[1]	Ghosn J, Taiwo B, Seedat S, et al. Hiv[J]. Lancet, 2018, 392(10148):685-697. DOI PMID
[2]	Brites C, Nogueira RS, Gosuen GC, et al. Short communication:getting older with HIV:increasing frequency of comorbidities and polypharmacy in Brazilian HIV patients[J]. AIDS Res Hum Retroviruses, 2019, 35(11/12):1103-1105. DOI URL
[3]	马中慧, 高洁, 曹东冬, 等. 德宏傣族景颇族自治州新报告HIV感染者多共病现况研究[J]. 中华疾病控制杂志, 2021, 25(12):1380-1386.
	Ma ZH, Gao J, Cao DD, et al. Prevalence and associated factors of multimorbidity among newly reported HIV-positive individuals in Dehong Dai and Jingpo Autonomous Prefecture[J]. Chin J Dis Control Prev, 2021, 25(12):1380-1386.
[4]	Global Burden of Disease Cancer Collaboration, Fitzmaurice C, Abate D, et al. Global,regional,and national cancer incidence,mortality,years of life lost,years lived with disability,and disability-adjusted life-years for 29 cancer groups,1990 to 2017:a systematic analysis for the global burden of disease study[J]. JAMA Oncol, 2019, 5(12):1749-1768. DOI PMID
[5]	Back D, Marzolini C. The challenge of HIV treatment in an era of polypharmacy[J]. J Int AIDS Soc, 2020, 23(2):e25449.
[6]	Masnoon N, Shakib S, Kalisch-Ellett L, et al. What is polypha-rmacy? A systematic review of definitions[J]. BMC Geriatr, 2017, 17(1):230. DOI PMID
[7]	Halloran MO, Boyle C, Kehoe B, et al. Polypharmacy and drug-drug interactions in older and younger people living with HIV:the POPPY study[J]. Antivir Ther, 2019, 24(3):193-201. DOI PMID
[8]	While A. Medication adherence:understanding the issues and finding solutions[J]. Br J Community Nurs, 2020, 25(10):474-479. DOI URL
[9]	Ware D, Frank J Palella J Jr, Chew KW, et al. Examination of polypharmacy trajectories among HIV-positive and HIV-negative men in an ongoing longitudinal cohort from 2004 to 2016[J]. AIDS Patient Care STDs, 2019, 33(8):354-365. DOI URL
[10]	Ulley J, Harrop D, Ali AL, et al. Deprescribing interventions and their impact on medication adherence in community-dwe-lling older adults with polypharmacy:a systematic review[J]. BMC Geriatr, 2019, 19(1):15. DOI URL
[11]	Mendenhall E, Bosire EN, Kim AW, et al. Cancer,chemotherapy,and HIV:living with cancer amidst comorbidity in a South African township[J]. Soc Sci Med, 2019, 237:112461. DOI URL
[12]	Malambo N, Erikson S. ‘Worse than HIV’:the logics of cancer screening avoidance in Swaziland[J]. Glob Public Health, 2018, 13(9):1276-1286. DOI URL
[13]	Jackson IL, Okonta JM, Ukwe CV. HIV and hypertension-related knowledge and medication adherence in HIV seropositive persons with hypertension[J]. J Public Health (Oxf), 2020.
[14]	Hing M, Hoffman RM, Seleman J, et al. ‘Blood pressure can kill You tomorrow,but HIV gives You time’:illness perceptions and treatment experiences among Malawian individuals living with HIV and hypertension[J]. Health Policy Plan, 2019, 34(Supplement_2):ii36-ii44. DOI URL
[15]	Muiruri C, Sico IP, Schexnayder J, et al. Why do people living with HIV adhere to antiretroviral therapy and not comorbid cardiovascular disease medications? A qualitative inquiry[J]. Patient Prefer Adherence, 2020, 14:985-994. DOI URL
[16]	Gervasoni C, Formenti T, Cattaneo D. Management of polypharmacy and drug-drug interactions in HIV patients:a 2-year experience of a multidisciplinary outpatient clinic[J]. AIDS Rev, 2019, 21(1):40-49. DOI PMID
[17]	Corrigan KL, Knettel BA, Ho N, et al. Improving access to cancer care in the HIV population:qualitative research to identify barriers to care[J]. Health Equity, 2020, 4(1):468-475. DOI PMID
[18]	Peer N, de Villiers A, Jonathan D, et al. Care and management of a double burden of chronic diseases:experiences of patients and perceptions of their healthcare providers[J]. PLoS One, 2020, 15(7):e0235710. DOI URL
[19]	袁双凤, 马丹丹, 刘瑞华. 艾滋病患者心理症状群及影响因素分析[J]. 临床心身疾病杂志, 2021, 27(3):149-151.
	Yuan SF, Ma DD, Liu RH. Analysis of psychological symptom group and its influencing factors of AIDS patients[J]. J Clin Psychosom Dis, 2021, 27(3):149-151.
[20]	Siefried KJ, Mao LM, Cysique LA, et al. Concomitant medication polypharmacy,interactions and imperfect adherence are common in Australian adults on suppressive antiretroviral the-rapy[J]. AIDS, 2018, 32(1):35-48. DOI PMID
[21]	Claborn KR, Meier E, Miller MB, et al. A systematic review of treatment fatigue among HIV-infected patients prescribed antiretroviral therapy[J]. Psychol Health Med, 2015, 20(3):255-265. DOI PMID
[22]	Claborn K, Miller MB, Meier E, et al. Development of a conceptual etiological model of treatment regimen fatigue among patients engaged in HIV care:a qualitative study[J]. J Assoc Nurses AIDS Care, 2017, 28(4):479-490. DOI PMID
[23]	Claborn KR, Miller MB, Meier E. Initial validation of the HIV treatment regimen fatigue scale for adults prescribed antiretroviral therapy[J]. J Assoc Nurses AIDS Care, 2015, 26(4):308-315. DOI PMID
[24]	Yang E, Mphele S, Moshashane N, et al. Distinctive barriers to antiretroviral therapy adherence among non-adherent adolescents living with HIV in Botswana[J]. AIDS Care, 2018, 30(2):224-231. DOI URL
[25]	Heckman BW, Mathew AR, Carpenter MJ. Treatment burden and treatment fatigue as barriers to health[J]. Curr Opin Psychol, 2015, 5:31-36. PMID
[26]	Beer L, Tie YF, Weiser J, et al. Nonadherence to any prescribed medication due to costs among adults with HIV infection - United States,2016-2017[J]. Morb Mortal Wkly Rep, 2019, 68(49):1129-1133.
[27]	Edelman EJ, Rentsch CT, Justice AC. Polypharmacy in HIV:recent insights and future directions[J]. Curr Opin HIV AIDS, 2020, 15(2):126-133. DOI URL
[28]	Bosire EN, Mendenhall E, Weaver LJ. Comorbid suffering:breast cancer survivors in South Africa[J]. Qual Health Res, 2020, 30(6):917-926. DOI PMID
[29]	余静, 谢幸尔, 钱湘云, 等. 艾滋病患者积极应对疾病的真实体验研究[J]. 中华护理杂志, 2021, 56(3):399-403. DOI
	Yu J, Xie XE, Qian XY, et al. AIDS patients using internal and external strength resources to cope with the disease:a qualitative research[J]. Chin J Nurs, 2021, 56(3):399-403.
[30]	Yang ZF, Zhu Z, Lizarondo L, et al. Experience of chronic noncommunicable disease in people living with HIV:a systematic review and meta-aggregation of qualitative studies[J]. BMC Public Health, 2021, 21(1):1651. DOI URL
[31]	Gonah L, Moodley I, Hlongwana K. Capacity of antiretroviral therapy sites for managing NCDs in people living with HIV in Zimbabwe[J]. South Afr J HIV Med, 2020, 21(1):1113.
[32]	Slomka J, Prince-Paul M, Webel A, et al. Multimorbidity with HIV:views of community-based people living with HIV and other chronic conditions[J]. J Assoc Nurses AIDS Care, 2017, 28(4):603-611. DOI URL
[33]	Guaraldi G, Malagoli A, Calcagno A, et al. The increasing burden and complexity of multi-morbidity and polypharmacy in geriatric HIV patients:a cross sectional study of people aged 65-74 years and more than 75 years[J]. BMC Geriatr, 2018, 18(1):99. DOI PMID
[34]	叶润华, 李静, 姚仕堂, 等. 德宏傣族景颇族自治州抗病毒治疗的HIV/AIDS糖尿病患病率及其相关因素分析[J]. 中华流行病学杂志, 2019, 40(6):654-659. PMID
	Ye RH, Li J, Yao ST, et al. Prevalence and related factors on diabetes among HIV/AIDS receiving antiretroviral therapy in Dehong Dai and Jingpo Autonomous Prefecture[J]. Chin J Epidemiol, 2019, 40(6):654-659. DOI PMID
[35]	邱珊娇, 唐干益, 黄文静, 等. Beers标准(2019)和中国老年人潜在不适当用药判断标准(2017版)评估社区老年共病患者的不适当用药分析[J]. 中国全科医学, 2020, 23(S1):34-38.
	Qiu SJ, Tang GY, Huang WJ, et al. Application of beers criteria(2019)and Chinese PIM criteria (2017 version) to evaluate inappropriate medication for elderly comorbid patients in communities[J]. Chin Gen Pract, 2020, 23(S1):34-38.
[36]	Perry NS, Remmert JE, Psaros C, et al. Learning to address multiple syndemics for people living with HIV through client perspectives on CBT[J]. Psychother Res, 2019, 29(4):492-502. DOI URL
[37]	高岩, 章清, 孙美艳, 等. HIV感染者/AIDS患者服药依从性管理的系统评价再评价[J]. 中华护理杂志, 2021, 54(4):604-610.
	Gao Y, Zhang Q, Sun MY, et al. Effectiveness of management of medication compliance to antiretroviral therapy in HIV/AIDS patients: an overview of reviews[J]. Chin J Nurs, 2021, 54(4):604-610.
[38]	廖敏, 唐杰, 王东华. HIV感染者和AIDS患者病耻感的研究进展[J]. 中华护理杂志, 2019, 54(4):619-623. DOI
	Liao M, Tang J, Wang DH. Research progress on stigma among HIV/AIDS patients[J]. Chin J Nurs, 2019, 54(4):619-623.
[39]	Manne-Goehler J, Siedner MJ, Montana L, et al. Hypertension and diabetes control along the HIV care cascade in rural South Africa[J]. J Int AIDS Soc, 2019, 22(3):e25213. DOI URL
[40]	Murudi-Manganye NS, Makhado L, Sehularo LA. Integrated ma-nagement of HIV and NCDs within the primary health care in the South African context:a comprehensive literature review[J]. Open Public Heal J, 2020, 13(1):447-454.
[41]	朱政, 胡雁, 赵蕊, 等. 艾滋病定点诊疗模式下症状管理的质性研究[J]. 中华护理杂志, 2019, 54(5):658-663. DOI
	Zhu Z, Hu Y, Zhao R, et al. Current situation of symptom management under the HIV/AIDS designed hospital system: a qualitative research[J]. Chin J Nurs, 2019, 54(5):658-663.