doi:院10.3761/j.issn.0254鄄1769.2019.06.030

Abstract

Key words: Negative-Pressure Wound Therapy, Instillation, Drug, Therapeutic Irrigation, Wound Infection, Nursing Care, Review

摘要：

围绕负压伤口治疗结合滴注冲洗的方法学研究及临床应用效果进行综述,从负压值的选择、冲洗溶液的选择、负压治疗与溶液冲洗的时间分配3个方面总结负压伤口治疗结合滴注冲洗的方法学研究结果;从维持性清创、减少细菌数量、去除细菌生物膜、缩短伤口愈合时间4个方面阐述其临床应用效果,旨在为推广和规范负压伤口治疗结合滴注冲洗疗法的临床应用提供参考。

关键词: 负压伤口疗法, 滴注, 药物, 灌洗疗法, 伤口感染, 护理, 综述

吴磊, 周济宏, 汤雨佳, 蒋琪霞. 负压治疗结合滴注冲洗在伤口护理中的应用进展[J]. 中华护理杂志, 2019, 54(6): 950-953.

References 33

[1]	蒋琪霞 . 伤口护理实践原则[M]. 北京: 人民卫生出版社, 2017.
[2]	蒋琪霞 . 负压封闭伤口治疗理论与实践[M]. 北京: 人民卫生出版社, 2018.
[3]	Yusuf E, Jordan X, Clauss M , et al. High bacterial load in negative pressure wound therapy(NPWT) foams used in the treatment of chronic wounds[J]. Wound Repair Regen, 2013,21(5):677-681. DOI URL
[4]	徐娟, 蒋琪霞, 刘颖 , 等. 给氧负压伤口治疗在骨科慢性伤口的应用效果研究[J]. 中华护理杂志, 2016,51(6):650-654.
[5]	Kim PJ, Attinger CE, Steinberg JS , et al. Negative pressure wound therapy with instillation:past,present,and future[J]. Surg Technol Int, 2015,26(3):51-56.
[6]	王晓蕊 . 封闭负压引流结合局部氧疗可有效治疗创伤性慢性伤口[J]. 基因组学与应用生物学, 2018,37(3):935-942.
[7]	Timmers MS, Graafland N, Bernards AT , et al. Negative pressure wound treatment with polyvinyl alcohol foam and polyhexanide antiseptic solution instillation in posttraumatic osteomyelitis[J]. Wound Repair Regen, 2009,17(2):278-286. DOI URL
[8]	蒋琪霞, 李晓华, 彭青 , 等. 负压伤口治疗技术用于53例慢性伤口的效果评价[J]. 中华护理杂志, 2012,47(4):293-296.
[9]	Back DA, Scheuermann-Poley C, Willy C . Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions-when,where and how to use:what does the evidence show?[J]. Int Wound J, 2013,10(Suppl 1):32-42. DOI URL
[10]	Sibbald RG, Coutts P, Woo KY . Reduction of bacterial burden and pain in chronic wounds using a new polyhexamethylene biguanide antimicrobial foam dressing-clinical trial results[J]. Adv Skin Wound Care, 2011,24(2):78-84. DOI URL
[11]	Landsman A, Blume PA, Jordan DAJr , et al. An open-label,three-arm pilot study of the safety and efficacy of topical Microcyn Rx wound care versus oral levofloxacin versus combined therapy for mild diabetic foot infections[J]. J Am Podiatr Med Assoc, 2011,101(6):484-496. DOI URL
[12]	Leung BK , LaBarbera LA, Carroll CA , et al. The effects of normal saline instillation in conjunction with negative pressure wound therapy on wound healing in a porcine model[J]. Wounds, 2010,22(7):179-187.
[13]	Kim PJ, Attinger CE, Oliver N , et al. Comparison of outcomes for normal saline and an antiseptic solution for negative-pressure wound therapy with Instillation[J]. Plast Reconstr Surg, 2015,136(5):657e-664e. DOI URL
[14]	黄素群, 甘秀妮, 宗建春 , 等. 碘伏冲洗在封闭负压疗法用于糖尿病足溃疡治疗中的护理研究[J]. 中华损伤与修复杂志(电子版), 2010,5(3):364-368.
[15]	王婧楠, 杨爱玲 . 洗必泰在骨科术后感染伤口VSD冲洗引流中的应用[J]. 浙江医学教育, 2016,15(1):55-57.
[16]	Gupta S, Gabriel A, Lantis J , et al. Clinical recommendations and practical guide for negative pressure wound therapy with instillation[J]. Int Wound J, 2016,13(2):159-174. DOI URL
[17]	罗小波, 张永刚, 马远征 , 等. 负压创面疗法联合滴注冲洗在骨科的临床应用标准研究进展[J]. 解放军医学院学报, 2016,37(5):518-521.
[18]	Gary Sibbald R, Goodman L, Reneeka P . Wound bed preparation 2012[J]. J Cutan Med Surg, 2013,17(Suppl 1):S12-22. DOI URL
[19]	Falanga V, Brem H, Ennis WJ , et al. Maintenance debridement in the treatment of difficult-to-heal chronic wounds. Recommendations of an expert panel[J]. Ostomy Wound Manage, 2008(Suppl):2-13.
[20]	Téot L, Boissiere F, Fluieraru S . Novel foam dressing using negative pressure wound therapy with instillation to remove thick exudate[J]. Int Wound J, 2017,14(5):842-848. DOI URL
[21]	Allen G, Kevin K, Riyad KJ . Use of negative pressure wound therapy with automated,volumetric instillation for the treat-ment of extremity and trunk wounds:clinical outcomes and potential cost-effectiveness[J]. Eplasty, 2014,14:e41.
[22]	Glass GE, Murphy GRF, Nanchahal J . Does negative-pressure wound therapy influence subjacent bacterial growth? A systematic review[J]. J Plast Reconstr Aesthet Surg, 2017,70(8):1028-1037. DOI URL
[23]	Matiasek J, Domig KJ, Djedovic G , et al. The effect of negative pressure wound therapy with antibacterial dressings or antiseptics on an in vitro wound model[J]. J Wound Care, 2017,26(5):236-242. DOI URL
[24]	Goss SG, Schwartz JA, Facchin F , et al. Negative pressure wound therapy with instillation(NPWTi) better reduces post-debridement bioburden in chronically infected lower extremity wounds than NPWT alone[J]. J Am Coll Clin Wound Spec, 2014,4(4):74-80.
[25]	Ludolph I, Fried FW, Kneppe K , et al. Negative pressure wound treatment with computer-controlled irrigation/instillation decreases bacterial load in contaminated wounds and facilitates wound closure[J]. Int Wound J, 2018,15(6):978-984. DOI URL
[26]	夏冬云, 史婷奇, 谢芳 , 等. 负压封闭引流创面冲洗频次对堵管及细菌清除率的影响[J]. 护理学杂志, 2014,29(16):1-3.
[27]	徐元玲, 王建东, 蒋琪霞 . 慢性伤口细菌生物膜的临床识别和影响因素的研究进展[J]. 医学研究生学报, 2014,27(12):1337-1339.
[28]	Tahir S, Malone M, Hu H , et al. The effect of negative pressure wound therapy with and without instillation on mature biofilms in vitro[J]. Materials, 2018,11(5):811. DOI URL
[29]	Phillips PL, Yang Q, Schultz GS . The effect of negative pressure wound therapy with periodic instillation using antimicrobial solutions on Pseudomonas aeruginosa biofilm on porcine skin explants[J]. Int Wound J, 2013,10(Suppl 1):48-55. DOI URL
[30]	Langer V, Bhandari PS, Rajagopalan S , et al. Negative pressure wound therapy as an adjunct in healing of chronic wounds[J]. Int Wound J, 2015,12(4):436-442. DOI URL
[31]	Liu Y, Tang N, Cao K , et al. Negative-pressure wound therapy promotes wound healing by enhancing angiogenesis through suppression of NLRX1 via miR-195 upregulation[J]. Int J Low Extrem Wounds, 2018,17(3):144-150. DOI URL
[32]	Gabriel A, Shores J, Heinrich C , et al. Negative pressure wound therapy with instillation:a pilot study describing a new method for treating infected wounds[J]. Int Wound J, 2008,5(3):399-413. DOI URL
[33]	Brinkert D, Ali M, Naud M , et al. Negative pressure wound therapy with saline instillation:131 patient case series[J]. Int Wound J, 2013,10(Suppl 1):56-60. DOI URL

负压治疗结合滴注冲洗在伤口护理中的应用进展

RichHTML

PDF

Knowledge

Abstract

Cite this article

share this article

References 33

Related Articles 15

Recommended Articles

Metrics

[1]	HUANG Panpan, LI Liling, HU Xiaojing. Research progress of early exercise rehabilitation in infants with congenital heart disease [J]. Chinese Journal of Nursing, 2025, 60(9): 1050-1055.
[2]	CHEN Liou, ZHANG Wenting, LIU Junqi, WANG Yuncong, WANG Zhenlin, QI Sai, YANG Na. Study on the effect of pulmonary lobes surface projection localization combined with pulmonary segment drainage and sputum expectoration technique on airway clearance in patients with aspiration pneumonia [J]. Chinese Journal of Nursing, 2025, 60(9): 1056-1061.
[3]	YANG Nana, CHENG Chuanli, ZENG Hui, FU Dandan, WANG Yan, CHEN Yue, RAN Hongmin, FAN Hongjing, LONG Xia. Evaluation of the effect of graded exercise rehabilitation on patients with acute exacerbation of chronic obstructive pulmonary disease [J]. Chinese Journal of Nursing, 2025, 60(9): 1062-1067.
[4]	CAO Yun, SUN Guozhen, CHEN Feng, JI Xueli, YAN Mengwan, JING Lei, QIAN Kun. A study of modified ankle pump exercise in stroke patients [J]. Chinese Journal of Nursing, 2025, 60(9): 1068-1074.
[5]	XIE Min, QI Wenkai, YIN Ling, ZHANG Xuan, ZHAO Ruqin. Potential profile analysis and influencing factors of kinesiophobia in patients with peritoneal dialysis [J]. Chinese Journal of Nursing, 2025, 60(9): 1080-1086.
[6]	CHEN Bingqian, ZHAO Bin, SUN Jiarong, HAO Sifang, HOU Xiaoli. Oral health management dilemmas of chronic periodontitis patients with implant dentures：a qualitative study [J]. Chinese Journal of Nursing, 2025, 60(9): 1087-1092.
[7]	QIN Chunlan, WU Zhenyun, QIAN Hongying, ZHAO Qian, SUN Jinting. Experiences of disease self-control among patients with chronic obstructive pulmonary disease：a qualitative study [J]. Chinese Journal of Nursing, 2025, 60(9): 1093-1098.
[8]	LI Ziwei, FENG Lijuan, CHEN Xusheng, HUANG Yi, YANG Jie. Development and application of a Fear of Movement Assessment Scale for patients with peripherally inserted central catheters [J]. Chinese Journal of Nursing, 2025, 60(9): 1099-1106.
[9]	CHENG Zhiqiang, ZHANG Baozhen, TANG Liping, LI Jing, XIA Jiaoyun, WEI Xueyan, GONG Zhixian, ZHANG Meizhen, LI Lusi. Reliability and validity test of the Chinese version of the Urinary Incontinence Awareness and Attitude Scale [J]. Chinese Journal of Nursing, 2025, 60(9): 1107-1112.
[10]	SHI Meiqin, WU Jianfang, ZHANG Duo, WU Chunping, CHEN Ling, TAO Lei. Nursing care for postoperative laryngeal function rehabilitation in a patient undergoing primary voice prosthesis implantation after total laryngectomy [J]. Chinese Journal of Nursing, 2025, 60(9): 1120-1123.
[11]	GU Qian, HUANG Xi, SHI Weixiong, WU Jing, TAN Ruoming, WANG Feng. Nursing care for a patient with cytokine release syndrome following T-cell immunotherapy [J]. Chinese Journal of Nursing, 2025, 60(9): 1124-1127.
[12]	ZHOU Miao, CHEN Xing, PENG Fei, SUN Shangxue, LI Yangyang. Systematic review of risk prediction instruments for central line associated bloodstream infections in ICU patients [J]. Chinese Journal of Nursing, 2025, 60(9): 1132-1139.
[13]	PENG Yingjie, LIU Aihong, ZHU Wenli, MEI Yuxin, ZHOU Meng, GUAN Wenjing. Systematic review of readiness assessment tools for advance care planning in older adults [J]. Chinese Journal of Nursing, 2025, 60(9): 1146-1153.
[14]	RAN Lingxiao, WANG Dongmin, XU Ke, WANG Cong, CAO Hua, CUN Wei, JIANG Yan. Application of biomechanical simulation based on three-dimensional human body model in preventing pressure ulcers：a scoping review [J]. Chinese Journal of Nursing, 2025, 60(8): 1012-1018.
[15]	JIN Yujia, JIANG Hu, WANG Xiaoxuan, YI Jingna, MEI Yongxia, GUO Zhiting, ZHANG Zhenxiang, LIN Beilei. Application of information-based risk communication in primary prevention of cardiovascular diseases：a scoping review [J]. Chinese Journal of Nursing, 2025, 60(8): 1019-1025.