Methodology and application of mixed methods systematic reviews

doi:10.3761/j.issn.0254-1769.2024.21.016

Abstract

Abstract:

Mixed methods systematic review（MMSR） is a type of review that comprehensively integrates qualitative and quantitative data to produce evidence to guide decision-making on a topic. This paper reviewed the application，method classification，specific implementation steps，and other methodological content of MMSR. At the same time，literature retrieval was used to analyze the published MMSR-related literature. According to the review results，MMSR can be divided into 2 main types：convergent approach and sequential approach. The domestic application started late and mainly focused on the patient’s physiological and emotional status. Therefore，the application scope of this method should be continuously expanded in medical and nursing in the future to adapt to social development and practical needs and continue to promote the development of MMSR standardization.

Key words: Mixed Methods Systematic Reviews, Review, Convergent Approach, Sequential Approach, Nursing Care

摘要：

混合方法研究系统评价（mixed methods systematic review，MMSR）是针对某一主题全面综合质性和量性数据，产生指导决策证据的综述类型。该文回顾了MMSR的内涵及应用情景、分类方法、实施步骤等方法学内容，并借助文献检索对已发表的MMSR相关研究进行文献分析，发现MMSR主要分为会聚方法、顺序方法2种类型，国内应用起步较晚，主要应用该方法探究患者的生理和情绪，因而未来可不断拓展其在医疗护理等领域的应用范围，以适应社会发展和实践需求，促进MMSR的规范发展。

关键词: 混合方法研究系统评价, 综述, 会聚方法, 顺序方法, 护理

CHEN Hongli, DING Xiaotong, WANG Qing, LI Zheng. Methodology and application of mixed methods systematic reviews[J]. Chinese Journal of Nursing, 2024, 59(21): 2665-2671.

陈红丽, 丁晓彤, 王青, 李峥. 混合方法研究系统评价的方法学及应用进展[J]. 中华护理杂志, 2024, 59(21): 2665-2671.

Figures/Tables 2

References 32

[1]	杨思兰, 李娟, 张杰, 等. 医学研究中常见的综述类型及相关方法分析[J]. 中华护理教育, 2020, 17(2):179-185.
	Yang SL, Li J, Zhang J, et al. The common review types and related review methods in medical research[J]. Chin J Nurs Educ, 2020, 17(2):179-185.
[2]	应钰皑, 孙蕊, 胡晨, 等. 运动锻炼对帕金森病患者睡眠质量影响的Meta分析[J]. 中华护理杂志, 2024, 59(4):482-490. DOI URL
	Ying YA, Sun R, Hu C, et al. Effectiveness of exercise on sleep quality in patients with Parkinson’s disease:a Meta-analysis[J]. Chin J Nurs, 2024, 59(4):482-490.
[3]	邓春燕, 杜兴梅, 冉凌云, 等. 非专业团体心理辅导对中国孕产妇抑郁症状影响的系统评价[J]. 中华护理教育, 2023, 20(6):707-715.
	Deng CY, Du XM, Ran LY, et al. Lay-delivered group psycho-therapy to relieve perinatal depressive symptoms in China:a systematic review[J]. Chin J Nurs Educ, 2023, 20(6):707-715.
[4]	谢晓冉, 徐蓉, 张静, 等. 局部氧疗对糖尿病足溃疡患者干预效果的Meta分析[J]. 中华护理杂志, 2023, 58(24):2976-2983. DOI URL
	Xie XR, Xu R, Zhang J, et al. The effect of topical oxygen therapy on the intervention of patients with diabetic foot ul-cers:a Meta-analysis[J]. Chin J Nurs, 2023, 58(24):2976-2983.
[5]	余莉莉, 宋涵, 王会宁, 等. 网络化认知行为疗法对乳腺癌康复期患者症状改善效果的Meta分析[J]. 中华护理杂志, 2024, 59(10): 1248-1254. DOI URL
	Yu LL, Song H, Wang HN, et al. A meta-analysis of symptom improvement effects of Internet-delivered cognitive-behavioral therapy in breast cancer survivors[J]. Chin J Nurs, 2024, 59(10):1248-1254. DOI URL
[6]	Stern C, Lizarondo L, Carrier J, et al. Methodological guidance for the conduct of mixed methods systematic reviews[J]. JBI Evid Synth, 2020, 18(10):2108-2118.
[7]	李文强, 褚红玲, 曾琳. 混合方法研究系统综述的证据综合与整合方法[J]. 中华儿科杂志, 2024, 62(1):35.
	Li WQ, Chu HL, Zeng L. Evidence synthesis and integration method of mixed method research system review[J]. Chin J Pediatr, 2024, 62(1):35.
[8]	廖星, 胡瑞学, 李博, 等. 混合方法研究评价工具的介绍:MMAT[J]. 中国全科医学, 2021, 24(31):4015-4020. DOI
	Liao X, Hu RX, Li B, et al. An introduction to mixed methods appraisal tool[J]. Chin Gen Pract, 2021, 24(31):4015-4020.
[9]	Hong QN, Pluye P, Bujold M, et al. Convergent and sequential synthesis designs:implications for conducting and reporting systematic reviews of qualitative and quantitative evidence[J]. Syst Rev, 2017, 6(1):61.
[10]	Pluye P, Hong QN. Combining the power of stories and the power of numbers:mixed methods research and mixed studies reviews[J]. Annu Rev Public Health, 2014, 35:29-45.
[11]	Sandelowski M, Voils CI, Barroso J. Defining and designing mixed research synthesis studies[J]. Res Sch, 2006, 13(1):29. PMID
[12]	Pearson A, White H, Bath-Hextall F, et al. A mixed-methods approach to systematic reviews[J]. Int J Evid Based Healthc, 2015, 13(3):121-131.
[13]	贺旭妍, 徐榕璟, 贾守梅. 混合方法系统评价的资料整合方法简介[J]. 护士进修杂志, 2024, 39(11):1121-1126.
	He XY, Xu RJ, Jia SM. Introduction to data integration methods for mixed methods systematic reviews[J]. J Nurs Train, 2024, 39(11):1121-1126.
[14]	王雪婷, 崔雪琴, 王右莎, 等. ICU患者口渴现状及其影响因素的混合方法研究系统评价[J]. 遵义医科大学学报, 2023, 46(5):505-513.
	Wang XT, Cui XQ, Wang YS, et al. The status and influencing factors of thirst in ICU patients:a mixed methods sys-tematic review[J]. J Zunyi Med Univ, 2023, 46(5):505-513.
[15]	Hong QN, Fàbregues S, Bartlett G, et al. The Mixed Methods Appraisal Tool(MMAT) version 2018 for information profes-sionals and researchers[J]. Educ Inf, 2018, 34(4):285-291.
[16]	Harrison R, Jones B, Gardner P, et al. Quality assessment with diverse studies(QuADS):an appraisal tool for methodological and reporting quality in systematic reviews of mixed or multimethod studies[J]. BMC Health Serv Res, 2021, 21(1):144. DOI PMID
[17]	Sirriyeh R, Lawton R, Gardner P, et al. Reviewing studies with diverse designs:the development and evaluation of a new tool[J]. J Eval Clin Pract, 2012, 18(4):746-752. DOI PMID
[18]	Frantzen KK, Fetters MD. Meta-integration for synthesizing data in a systematic mixed studies review:insights from research on autism spectrum disorder[J]. Qual Quant, 2016, 50(5):2251-2277.
[19]	Dixon-Woods M, Agarwal S, Jones D, et al. Synthesising quali-tative and quantitative evidence:a review of possible methods[J]. J Health Serv Res Policy, 2005, 10(1):45-53. DOI PMID
[20]	张凤云. 定量型数据转化为定性数据关联规则挖掘方法[J]. 潍坊学院学报, 2019, 19(2):16-20.
	Zhang FY. Quantitative data transformation into qualitative data association rules mining method[J]. J Weifang Univ, 2019, 19(2):16-20.
[21]	Krippendorff K. Content Analysis. An introduction to its me-thodology[M]. London: Sage Publications Inc, 2004.
[22]	Voils C, Hassselblad V, Crandell J, et al. A Bayesian method for the synthesis of evidence from qualitative and quantitative reports:the example of antiretroviral medication adherence[J]. J Health Serv Res Policy, 2009, 14(4):226-233.
[23]	Rihoux B, Ragin C. Configurational comparative methods:qua-litative comparative analysis(QCA) and related techniques[M]. Thousand Oaks: Sage Publications Inc, 2009.
[24]	Walsh D, Downe S. Meta-synthesis method for qualitative re-search:a literature review[J]. J Adv Nurs, 2005, 50(2):204-211.
[25]	Ahn E, Kang H. Introduction to systematic review and meta-analysis[J]. Korean J Anesthesiol, 2018, 71(2):103-112. DOI PMID
[26]	Page MJ, Moher D, Bossuyt PM, et al. PRISMA 2020 explana-tion and elaboration:updated guidance and exemplars for reporting systematic reviews[J]. BMJ, 2021, 372:n160.
[27]	马书丽, 杨晓曦, 刘谆谆, 等. 急性胰腺炎患者负性情绪现状及其影响因素的混合系统评价[J]. 解放军护理杂志, 2021, 38(7):6-9,15.
	Ma SL, Yang XX, Liu ZZ, et al. Negative emotion in patients with acute pancreatitis and its risk factors:a mixed methods systematic review[J]. Nurs J Chin PLA, 2021, 38(7):6-9,15.
[28]	卢青文. 肝癌晚期患者缓和照护认知现况及影响因素的研究[D]. 上海: 海军军医大学, 2023.
	Lu QW. Study on cognitive status and influencing factors of palliative care in patients with advanced liver cancer[D]. Shanghai: Naval Medical University, 2023.
[29]	王文娜, 孙倩倩, 梅永霞, 等. 基于二元视角的脑卒中患者自我护理影响因素混合研究系统评价[J]. 军事护理, 2023, 40(8):67-71.
	Wang WN, Sun QQ, Mei YX, et al. Systematic review of mixed research on influencing factors of stroke survivors’ self-care based on dyadic perspective[J]. Mil Nurs, 2023, 40(8):67-71.
[30]	韩知浩, 马小琴. 癌症晚期患者代理决策者预立医疗照护计划参与度影响因素的混合方法系统评价[J]. 中国全科医学, 2023, 26(22):2785-2792. DOI
	Han ZH, Ma XQ. Influencing factors of advance care planning participation in surrogate decision maker of advanced cancer patients:a mixed methods systematic review[J]. Chin Gen Pract, 2023, 26(22):2785-2792.
[31]	Wallin V, Omerov P, Mattsson E, et al. Experiences of food and mealtime from the perspective of patients with chronic life-limiting disease:a mixed-method systematic review[J]. J Adv Nurs, 2021, 77(11):4400-4413.
[32]	Hughes NM, Noyes J, Eckley L, et al. What do patients and family-caregivers value from hospice care? A systematic mixed studies review[J]. BMC Palliat Care, 2019, 18(1):18. DOI PMID