Abstract:

Objective To investigate the status of adult patients with Cushing’s disease and its influencing factors,and to provide evidence for optimizing the quality of the patients.Methods The cross-sectional survey was carried out from November 2018 to June 2020 among adult patients with Cushing’s disease recruited by convenience sampling in a single center. Research instruments included the General Information Questionnaire,Chinese version of Cushing’s syndrome patients’ quality of life questionnaire,PHQ-9 depression screening scale,GAD-7 self-assessment scale,Karnofsky functional status rating scale. Data cleaning,statistical description,single factor analysis and multivariate regression analysis were completed with SPSS 23.0 software.Results The score of the quality of life in patients with Cushing’s disease was（46.49±20.58）. The results of multivariate regression analysis showed that cortisol level,depression and anxiety were risk factors of low quality of life in patients with Cushing’s disease（P<0.05）.Conclusion The quality of life of adult patients with Cushing’s disease is not high. Medical staff should pay more attention to patients with Cushing’s disease with high cortisol level,depression and anxiety,and try to prevent the occurrence of risk factors and implement targeted interventions and care as soon as possible once any risk factors are identified.

Key words: Cushing’s Disease, Quality of Life, Depression, Anxiety, Nursing Care

摘要：

目的 了解成年库欣病患者生活质量的现状,并探究其影响因素,为改善库欣病患者生活质量提供依据。方法 2018年11月—2020年6月,采用方便抽样法,选择上海市某三级甲等医院142例成年库欣病住院患者,采用一般资料调查表、中文版库欣病患者生活质量调查问卷、中文版健康问卷抑郁量表、中文版广泛性焦虑量表、卡氏功能状态评分表等进行调查,将单因素分析有统计学意义的变量进行多元线性回归分析。结果 库欣病患者生活质量量表标准化得分为（46.49±20.58）分,多元线性回归分析结果发现,皮质醇水平、抑郁和焦虑是库欣病患者低生活质量的危险因素（P<0.05）。结论 成年库欣病患者生活质量较低,护理人员应重点关注皮质醇高、抑郁和焦虑的库欣病患者,预防危险因素的发生,并在发生后给予针对性干预和照护。

关键词: 库欣病, 生活质量, 抑郁, 焦虑, 护理