Abstract:

This case report summarizes the nursing experience in ensuring medication safety during intranasal esketamine spray treatment for a patient with treatment-resistant depression. Key nursing interventions included：pre-treatment assessment of concomitant medication risks，preparation of staff，environment，and medications；during treatment，strict adherence to administration protocols with simultaneous respiratory function monitoring and nasal tolerability assessment to minimize respiratory depression risk；post-treatment blood pressure surveillance combined with longitudinal symptom tracking and dynamic suicide risk evaluation for self-harm prevention；reinforcement of adverse reaction prevention and management. After completing the full 4-week treatment course（8 sessions），the patient exhibited the improved depressive symptoms and the reduced suicidal ideation，and the patient was successfully discharged.

Key words: Intranasal Esketamine Spray Treatment, Depression, Treatment-Resistant, Suicide, Adverse Reaction, Nursing Care

摘要：

总结1例难治性抑郁症患者使用症艾司氯胺酮鼻喷雾剂治疗时安全用药的护理经验。护理要点：用药前评估患者联合用药风险，做好人员、环境及药物准备；用药中严格遵循给药规范，监测呼吸与鼻咽部耐受性，警惕呼吸抑制；用药后监测血压，持续跟踪抑郁症状变化，动态识别自杀预警信号，防止自我伤害事件的发生；全程加强不良反应的预防与护理。经过共8次4周的治疗，患者抑郁情绪改善，自杀意念减少，并顺利出院。

关键词: 艾司氯胺酮鼻腔喷雾剂, 抑郁症, 难治性, 自杀, 不良反应, 护理