关键词: 肺移植, 衰弱, 影响因素分析, Meta分析, 循证护理学

Abstract:

Objective To identify the factors associated with frailty in lung transplant patients by a meta-analysis. Methods Computerized search was performed for studies on the influencing factors of frailty in lung transplant patients in the CNKI， WanFangData， VIP， CBM， PubMed， Web of Science， Embase， Elsevier ScienceDirect and CINAHL databases. The search was conducted from the time of database construction to November 2023. Literature screening， quality assessment， and data extraction were performed independently by 2 investigators， and Meta-analysis was performed using Stata 17.0 software. Results 10 cohort studies， including 1 999 patients， were finally included， and 13 influencing factors were extracted， including advanced age （OR=1.05）， female （OR=2.50）， BMI （OR=0.38）， diagnosis of primary pulmonary disease （OR=2.90）， 6MWD （OR=0.34）， and lung allocation score （OR=0.69）， FVC （OR=0.60）， pre-transplant frailty （OR=0.81）， hypoproteinemia （OR=4.12）， hemoglobin （OR=0.50）， anemia （OR=4.37）， length of ICU stay （OR=1.24）， and total length of stay （OR=1.05）. Short Physical Performance Battery is an assessment tool for frailty in lung transplant patients， with an incidence of frailty in 24% before transplantation and 50% in post-transplantation. Fried Frailty Phenotype is an assessment tool for frailty in lung transplant patients， with a pre-transplant frailty incidence of 30%. Conclusion There are many factors involved in the incidence of frailty in lung transplant patients， and nursing staff should dynamically evaluate the frailty of lung transplant patients， and give individualized and precise interventions in combination with a multidisciplinary model to improve or delay the progression of frailty.

Key words: Lung Transplantation, Frailty, Root Cause Analysis, Meta-Analysis, Evidence-Based Nursing