Objective To construct an interdisciplinary collaborative care model led by specialty nurses under the hospital-wide bed-sharing model,and to explore its application effects,aiming to improve nursing efficiency and enhance nursing quality. Methods Based on collaborative nursing theory,combined with the healthy work environment framework,an interdisciplinary collaborative care model led by specialty nurses was constructed through literature review and expert meetings,including 6 dimensions:communication,collaboration,decision-making,human resources,value,and leadership. Using purposeful sampling,specialty nurses and interdisciplinary admitted patients from a tertiary general hospital in Zhejiang Province in 2024 were selected as the application subjects. The proportion of interdisciplinary admitted patients,incidence of adverse events,patient satisfaction,average patient hospitalization days,specialty nursing consultation rate,and the collaborative ability and healthy work environment perception level of specialty nurses before(2023) and after(2024) the application of the model were described and compared. Results After implementation of the model,the proportions of interdisciplinary admitted patients,specialty nurses consultation rates,collaborative competence of specialty nurses,and perceived levels of a healthy work environment were significantly higher than those before implementation,with statistically significant differences(P<0.001). The comparison of adverse event incidence rates before and after the model implementation showed no statistically significant difference(P>0.05). Patient satisfaction scores were 97.94 points after implementation of the model and 98.48 points before implementation;the average length of hospital stay was 5.00 days post-implementation and 4.87 days pre-implementation. Conclusion The application of the interdisciplinary collaborative care model led by specialty nurses helps to integrate specialty nursing resources,enhances the collaborative ability and healthy work environment perception level of specialty nurses,and can provide a practical pathway for interdisciplinary collaborative care under the hospital-wide bed-sharing model.