Objective To develop a postoperative self-management question prompt list for adult liver transplant recipients and conduct preliminary application,aiming to provide an effective tool for facilitating their engagement in postoperative self-management. Methods From August to September 2024,the first draft of the postoperative self-management question prompt list for adult liver transplant recipients was developed through literature search and qualitative interviews,including 9 primary items and 50 secondary items. From October to November 2024,16 experts from Qingdao,Jinan,Beijing,and Fuzhou were interviewed on the Delphi method for 2 rounds to revise the question prompt list. From February to March 2025,19 patients after liver transplantation were selected for the preliminary application of the question prompt list. Results The response rates in the 2 rounds of consultations were both 100% and the authority coefficients of experts were both 0.88. The Kendall’s W in the 2 rounds was 0.336 and 0.344(P<0.001),respectively. The final question prompt list includes 9 primary items and 49 secondary items. The study showed that QPL demonstrated high clinical practicability in helping patients systematically understand the self-management framework after liver transplantation, promoting doctor-patient communication, and enhancing the initiative of self-management. Conclusion The question prompt list of postoperative self-management for adult liver transplant recipients established in this study is scientific,reliable,and practical,which is helpful for patients to obtain information about self-management from medical staff.