Objective To construct an exercise intervention scheme for postoperative colorectal cancer patients and evaluate its application. Methods The research team summarized the evidence on exercise recommendations for patients with colorectal cancer(CRC) and constructed an exercise intervention scheme through group discussion,expert consultation,semi-structured interviews,and onsite consultation. Patients with CRC admitted to the Department of Colorectal Surgery of a tertiary A hospital in Jilin province were selected as the study subjects by a convenience sampling method from October 2023 to March 2024. The test group and the control group included 35 patients in each group. The test group received basic nursing and exercise intervention,the control group received basic nursing and knowledge-based education. The 2 groups were compared in terms of physical activity, number of 30 s chair-stand test,and physical activity compliance score at 1 week post-intervention and 1 month post-intervention. Results There were 4 cases dropped in the test group and 3 cases dropped in the control group. The results of repeated measures ANOVA showed that there were between-group and time interaction effects for walking time,sedentary time,and the number of chair stands in 30 s in the 2 groups(P<0.05). The experimental group’s walking time,sedentary time,the number of chair stands in 30 s,moderate physical activity time and the physical activity compliance scores were better than those of the control group after the intervention,and the differences were statistically significant(P<0.05). Conclusion This exercise intervention based on a multi-theory model significantly increased the moderate physical activity time and walking time,decreased the sedentary time and improved compliance with physical activity recommendations, which may improve lower limb muscle strength in postoperative colorectal cancer patients.