Objective To construct a rehabilitation care platform for spinal cord injury patients,based on patient portrait technology and to validate its application effect. Methods Artificial intelligence technology was used to realize the fusion of data. We constructed a patient portrait rehabilitation nursing system that can provide systematic and personalized information support. By the convenience sampling method,53 perioperative patients with spinal cord injury from July 2023 to December 2023 were selected as the test group to implement the intelligent intervention based on patient portrait technology;53 perioperative patients with spinal cord injury who were hospitalized from January 2023 to June 2023 were selected as the control group to implement the conventional information support intervention. The self-efficacy,self-care ability,and quality of life were compared before the intervention,and 2 weeks,4 weeks,12 weeks after the intervention between the 2 groups. Results 45 cases in the experimental group and 43 cases in the control group reached the endpoint of the study after 12 weeks of intervention. The ANOVA of the 2 groups showed the test group having a greater advantage over the control group,with statistically significant differences in self-efficacy,ability to perform daily living tasks,and quality of life between groups,intergroup effect,and interaction effect(P<0.05). Conclusion The rehabilitation care platform based on patient portraits has a positive effect on improving self-efficacy,self-care ability and quality of life for spinal cord injury patients.