Abstract:

Objective To evaluate the effect of aerobic combined resistance exercise in children with malignant tumors. Methods We searched databases including Wanfang,VIP,CNKI,CBM,Web of Science,Cochrane Library,PubMed,Embase and CINAHL,from inception to May 2021,and we included randomized controlled trials（RCTs） reporting the effectiveness of aerobic combined resistance exercise in children with malignant tumors. 2 trained researchers screened the literature,evaluated the quality and extracted the data independently,and the meta-analysis was implemented with RevMan 5.4. Results Totally 7 RCTs involving 452 children were included. The results of meta-analysis showed that after exercise intervention,the cancer-related fatigue[SMD=-1.07,95%CI（-1.60,-0.53）,P<0.01] and 6-minute walk test[SMD=0.83,95%CI（0.47,1.19）,P<0.01] of children in the experimental group are better than those in the control group. There were no statistically significant differences in peak oxygen uptake [SMD=-0.08,95%CI（-0.42,0.26）,P=0.63] and health-related quality of life[SMD=-0.09,95%CI（-0.44,0.26）,P=0.62]. Conclusion Aerobic combined with resistance exercise can alleviate cancer-related fatigue in children with malignant tumors and enhance their cardiopulmonary function. However,the conclusion of this study needs to be confirmed by further high quality research.

Key words: Neoplasm, Child, Aerobic Exercise, Resistance Exercise, Meta-Analysis, Nursing Care

摘要：

目的 评价有氧运动结合抗阻运动在恶性肿瘤患儿中的干预效果。 方法 计算机检索万方、维普、中国知网、中国生物医学文献数据库、Web of Science、Cochrane Library、PubMed、Embase、CINAHL数据库中关于有氧运动结合抗阻运动对恶性肿瘤干预效果的随机对照试验,检索时限为建库至2021年5月。由2名经过培训的研究人员独立对文献进行筛选、质量评价和资料提取,采用RevMan 5.4软件进行Meta分析。 结果 共纳入7篇文献,总计452例恶性肿瘤患儿。Meta分析结果显示,运动干预后试验组癌因性疲乏得分低于对照组[SMD=-1.07,95%CI（-1.60,-0.53）,P<0.01]、6 min步行距离远于对照组[SMD=0.83,95%CI（0.47,1.19）,P<0.01],差异具有统计学意义;在峰值摄氧量[SMD=-0.08,95%CI（-0.42,0.26）,P=0.63]、健康相关生活质量[SMD=-0.09,95%CI（-0.44,0.26）,P=0.62]方面,差异无统计学意义。 结论 有氧运动结合抗阻运动能缓解恶性肿瘤患儿癌因性疲乏,增强其心肺功能,但仍需更多高质量的随机对照试验进一步证实。

关键词: 肿瘤, 儿童, 有氧运动, 抗阻运动, Meta分析, 护理