Abstract:

Objective To retrieve，evaluate and summarize domestic and foreign available evidence on the management of fatigue in patients with hematopoietic stem cell transplant（HSCT），so as to provide references for clinical evidence-based practice. Methods We systematically searched domestic and foreign computer decision support systems，guideline websites，databases，and relevant society websites for evidence on the management of fatigue in patients with HSCT，including guidelines，clinical decision-making，recommended practices，evidence summaries，systematic reviews，and expert consensuses published from the establishment of the databases or websites to February 10，2022. There were 2 researchers who evaluated the quality of the included literature independently，and combined the professional judgement with information extraction. Results A total of 24 pieces of literature were eligible for inclusion，including 4 clinical guidelines，2 evidence summaries，1 expert consensus and 17 systematic reviews. There were 24 pieces of best evidence with 8 dimensions being summarized，namely assessment，exercise management，psychosocial interventions，health education，nutritional therapy，complementary and alternative therapies，rational drug use，and shared decision-making and multidisciplinary collaboration. Conclusion Nursing staff should pay attention to the management of fatigue in patients with HSCT，and manage patients’ fatigue in a standardized，effective，and safe way according to characteristics of clinical environment and patients’ preferences，so as to improve their prognosis and quality of life.

Key words: Hematopoietic Stem Cell Transplantation, Fatigue, Evidence Summary, Evidence-Based Nursing

摘要：

目的 检索、评价并总结国内外关于造血干细胞移植患者疲乏管理的最佳证据，为临床开展相关循证护理实践提供参考。 方法 系统检索国内外计算机决策支持系统、指南网站、数据库、相关专业协会网站中关于造血干细胞移植患者疲乏管理的证据，包括指南、临床决策、推荐实践、证据总结、系统评价及专家共识。检索时间为建库至2022年2月10日。由2名研究者独立对文献质量进行评价，并结合专业判断进行资料提取、整合。 结果 共纳入24篇文献，其中指南4篇、专家共识1篇、证据总结2篇、系统评价17篇。总结的最佳证据包括疲乏的评估、运动管理、心理社会干预、健康教育、营养管理、补充和替代疗法、合理用药、共同决策和多学科合作8个方面，共24条。 结论 临床护理人员需要重视造血干细胞移植患者的疲乏管理，应根据临床实际情况和患者意愿，以规范、有效、安全的方式管理疲乏，以改善其预后和生活质量。

关键词: 造血干细胞移植, 疲乏, 证据总结, 循证护理学