Abstract:

Objective To evaluate the systematic reviews of the effect of computerized cognitive training on patients with mild cognitive impairment. Methods PubMed，Cochrane Library，Embase，Joanna Briggs Institute，Wan Fang Data，CNKI，CBM and VIP were searched by the computer to collect systematic reviews or meta-analysis of the effect of computerized cognitive training intervention on mild cognitive impairment patients. 2 researchers independently conducted 1iterature search and data extraction. AMSTAR 2 scale and GRADE system were used to evaluate the methodological quality and evidence quality of the included literature. We excluded the overlapping randomized controlled trials （RCTs） and performed a re-meta-analysis of the primary RCTs. Results A total of 10 systematic reviews/meta-analyses were included. The methodological quality evaluation by AMSTAR 2 showed that the quality of studies was generally low，with a low study and 10 extremely low ones. The results showed that computerized cognitive training is beneficial to improve patients’ holistic cognition，while the efficacy of executive function，memory function and attention needs to be further confirmed. Conclusion Computerized cognitive training can provide positive influences on cognitive function of patients with mild cognitive impairment. Limited by the quantity and quality of the included studies，a large sample and high-quality studies are still needed to further confirm the reliability of this conclusion.

Key words: Computerized Cognitive Training, Mild Cognitive Impairment, Overview of Systematic Reviews, Meta-Analysis, Geriatric Nursing, Aged

摘要：

目的 对计算机化认知训练对轻度认知障碍患者干预效果的系统评价再评价，为开展计算机化认知训练提供证据支持。 方法 计算机检索PubMed、Cochrane Library、Embase、澳大利亚乔安娜布里格斯研究所（Joanna Briggs Institute，JBI）循证卫生保健中心数据库、万方数据库、中国知网、中国生物医学文献数据库、维普数据库，检索内容涉及计算机化认知训练对轻度认知障碍患者干预效果的系统评价/Meta分析，检索时限为建库至2021年12月。由2名研究者独立进行文献筛选、分别对纳入的系统评价和结局指标进行质量评价。排除重复的随机对照试验（randomized controlled trials，RCT），并对主要RCT重新进行Meta分析。 结果 最终纳入10篇系统评价/Meta分析，系统评价方法学质量评价结果显示，1篇为中等质量，其余均为低或较低质量。结果显示，计算机化认知训练有助于改善轻度认知障碍患者的整体认知功能，但对执行功能、记忆功能、注意功能等的干预效果仍需进一步证实。 结论 计算机化认知训练有助于改善轻度认知障碍患者的认知功能，受纳入研究的数量及质量限制，尚需要大样本、高质量的研究进一步证实该结论的可靠性。

关键词: 计算机化认知训练, 轻度认知障碍, 系统评价再评价, Meta分析, 老年护理学, 老年人