关键词: 极早发型炎症性肠病, 白介素-10突变, 脐血干细胞移植, 营养管理, 儿科护理学

Abstract:

The nutritional management of a child with very early-onset inflammatory bowel disease during umbilical cord blood stem cell transplantation is summarized. The key points of nursing care are as follows. Before hematopoietic stem cell transplantation，multiple methods were combined to conduct early nutritional screening and assessment to clearly identify the status of malnutrition，a personalized enteral nutrition plan was developed to reduce discomfort symptoms，and trace elements and vitamins were supplemented to maintain the balance of the internal environment. During chemotherapy period and transplantation period， parenteral nutrition protocols were initiated to alleviate gastrointestinal reactions during chemotherapy. After hematopoietic stem cell transplantation，personalized transition strategies were implemented，and extraenteral and enteral nutrition were promoted；the complementary foods were added as required to meet the developmental needs；based on multidisciplinary collaboration，the transition from tube feeding to oral feeding is achieved. After 153 days of treatment and nursing care，the child’s IL-10 signaling pathway function returned to normal，the nutritional status was improved，and catch-up growth was achieved.

Key words: Early-Onset Inflammatory Bowel Disease, IL-10 Mutation, Umbilical Cord Blood Stem Cell Transplantation, Nutritional Management, Pediatric Nursing