多发性骨髓瘤患者运动干预的最佳证据总结

doi:10.3761/j.issn.0254-1769.2024.11.006

摘要/Abstract

摘要：

目的检索、评价及总结多发性骨髓瘤患者运动干预的相关证据，为医护人员指导患者开展运动干预提供参考。方法通过计算机系统检索国内外指南网、相关专业学会网站、数据库中关于多发性骨髓瘤患者运动干预的临床决策、推荐实践、指南、证据总结、专家共识、系统评价及随机对照试验。检索时限为建库至2023年5月。由2名研究者独立进行文献质量评价、证据提取及整合。结果最终纳入13篇文献，其中指南2篇、系统评价8篇、专家共识2篇、随机对照试验1篇。从运动干预的有效性、适应证及禁忌证、运动干预前评估、运动干预的方式和强度、运动干预的管理5个方面总结了23条最佳证据。结论该研究总结了多发性骨髓瘤患者运动干预的证据，建议医护人员在应用证据时充分考虑临床实际情况，结合患者病情及意愿，为其提供个性化的运动指导。

关键词: 多发性骨髓瘤, 运动干预, 证据总结, 循证护理学

Abstract:

Objective To search，evaluate and summarize the relevant evidence of exercise intervention for patients with multiple myeloma，and provide references for medical staff to guide patients to carry out exercise intervention. Methods The researchers conducted a systematical search in national and international databases，relevant guideline websites and professional society websites for related clinical decisions，recommended practices，guidelines，evidence summaries，expert consensuses，and systematic reviews for exercise intervention in patients with multiple myeloma since establishment of databases to May 2023. The quality evaluation，extraction and integration for evidence were conducted independently by 2 researchers，respectively. Results A total of 13 studies，including 2 guidelines，8 systematic reviews，2 expert consensuses and 1 randomized controlled trial，were included. There were 23 pieces of best evidence with 5 dimensions，including the exercise intensity effectiveness，contraindications and indications，exercise pre-intervention evaluation，exercise intervention style and intensity，and exercise intervention management. Conclusion The study summarized the best evidence of exercise intervention for patients with multiple myeloma. It is recommended for health professionals to fully consider the clinical situations to develop more detailed personalized exercise intervention programs based on patients’ own situation.

Key words: Multiple Myeloma, Exercise Intervention, Evidence Summary, Evidence-Based Nursing

马丽君, 李娜, 尹钰煊, 杨慧, 刘伟, 姚晶, 别亚文. 多发性骨髓瘤患者运动干预的最佳证据总结[J]. 中华护理杂志, 2024, 59(11): 1324-1331.

MA Lijun, LI Na, YIN Yuxuan, YANG Hui, LIU Wei, YAO Jing, BIE Yawen. Evidence summary of exercise intervention in patients with multiple myeloma[J]. Chinese Journal of Nursing, 2024, 59(11): 1324-1331.

图/表 5

表1 PubMed检索策略

Table 1 Search strategies in PubMed

图1 文献筛选流程

Figure 1 Flow chart of literature screening

表2 纳入文献的一般特征（n=13）

Table 2 Characteristics of included studies（n=13）

表3 纳入指南的质量评价结果（n=2）

Table 3 Quality evaluation of guidelines（n=2）

表4 多发性骨髓瘤患者运动干预的最佳证据总结

Table 4 Summary of the best evidence for exercise intervention in patients with multiple myeloma

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