中华护理杂志 ›› 2026, Vol. 61 ›› Issue (8): 1148-1152.DOI: 10.3761/j.issn.0254-1769.2026.08.020
• 综述 • 上一篇
收稿日期:2025-08-09
出版日期:2026-04-20
发布日期:2026-04-22
*通讯作者:
许翠萍,E-mail:xucuiping775@sohu.com作者简介:李琰:男,本科(硕士在读),E-mail:1356493358@qq.com李琰:论文撰写、论文修改;许翠萍:研究指导、论文修改
Received:2025-08-09
Online:2026-04-20
Published:2026-04-22
* Corresponding author:
XU Cuiping,E-mail:xucuiping775@sohu.com摘要:
数字生物标志物是指通过数字健康技术获取且能够动态反映患者在自然情况下的生理、病理状况或预测疾病风险的生物学指标,具有客观性、连续性、低监测负担性等特点,可指导癌症患者的临床决策与护理干预。该文对数字生物标志物的数据类型、收集工具,以及在癌症患者疾病筛查、病情评估等方面的应用情况进行综述,并提出应用挑战和对策,旨在为数字生物标志物在国内癌症患者护理中的应用提供参考。
李琰, 许翠萍. 数字生物标志物在癌症患者中的应用进展及护理启示[J]. 中华护理杂志, 2026, 61(8): 1148-1152.
LI Yan, XU Cuiping. Recent advances in the application of digital biomarkers for disease assessment and monitoring in cancer patients[J]. Chinese Journal of Nursing, 2026, 61(8): 1148-1152.
| [1] | Han BF, Zheng RS, Zeng HM, et al. Cancer incidence and mor-tality in China,2022[J]. J Natl Cancer Cent, 2024, 4(1):47-53. |
| [2] |
Fang X, Ren K, Li Y, et al. Prevalence and influencing factors of social alienation among elderly patients undergoing radical prostatectomy for prostate cancer[J]. Curr Urol, 2024, 18(2):98-103.
DOI URL |
| [3] |
Song CN, Yao LB. The experience of social alienation in elderly lung cancer patients:a qualitative study[J]. Asian Nurs Res, 2024, 18(3):281-287.
DOI URL |
| [4] |
Garbey M, Lesport Q, Öztosun G, et al. Improving care for amyo-trophic lateral sclerosis with artificial intelligence and affective computing[J]. J Neurol Sci, 2025, 468:123328.
DOI URL |
| [5] |
Oakley-Girvan I, Zhai YY, Yunis R, et al. Analysis method of real-world digital biomarkers for clinical impact in cancer patients[J]. Digit Biomark, 2025, 9(1):40-51.
DOI PMID |
| [6] |
Haghayegh F, Norouziazad A, Haghani E, et al. Revolutionary point-of-care wearable diagnostics for early disease detection and biomarker discovery through intelligent technologies[J]. Adv Sci, 2024, 11(36):2400595.
DOI URL |
| [7] | Bera K, Braman N, Gupta A, et al. Predicting cancer outcomes with radiomics and artificial intelligence in radiology[J]. Nat Rev Clin Oncol, 2022, 19(2):132-146. |
| [8] | Kos M, Pijnappel EN, Buffart LM, et al. The association bet-ween wearable activity monitor metrics and performance status in oncology:a systematic review[J]. Support Care Cancer, 2021, 29(11):7085-7099. |
| [9] | Cloβ K, Verket M, Müller-Wieland D, et al. Application of wea-rables for remote monitoring of oncology patients:a scoping review[J]. Digit Health, 2024, 10:20552076241233998. |
| [10] |
Brown MS, Browne K, Kirchner N, et al. Adhesive-free,stretc-hable,and permeable multiplex wound care platform[J]. ACS Sens, 2022, 7(7):1996-2005.
DOI URL |
| [11] | Cheng N, Du D, Wang XX, et al. Recent advances in bio-sensors for detecting cancer-derived exosomes[J]. Trends Bio-technol, 2019, 37(11):1236-1254. |
| [12] | Bi WL, Hosny A, Schabath MB, et al. Artificial intelligence in cancer imaging:clinical challenges and applications[J]. CA Cancer J Clin, 2019, 69(2):127-157. |
| [13] |
郭俊晨, 刘超毅, 许湘华, 等. 终末期癌症患者远程居家安宁疗护照护系统的构建及应用研究[J]. 中华护理杂志, 2024, 59(16):1925-1933.
DOI URL |
| Guo JC, Liu CY, Xu XH, et al. Construction and application of a remote home hospice care system for patients with end-stage cancer[J]. Chin J Nurs, 2024, 59(16),1925-1933. | |
| [14] |
李鹤, 章梅云, 俞素芬, 等. 智能化癌性疼痛患者出院随访系统的构建及应用[J]. 中华护理杂志, 2024, 59(13):1562-1567.
DOI URL |
| Li H, Zhang MY, Yu SF, et al. Construction and application of an intelligent discharge follow-up system for cancer pain patients[J]. Chin J Nurs, 2024, 59(13):1562-1567. | |
| [15] | Basch E, Deal AM, Kris MG, et al. Symptom monitoring with patient-reported outcomes during routine cancer treatment:a randomized controlled trial[J]. J Clin Oncol, 2016, 34(6):557-565. |
| [16] |
Mathunjwa BM, Kor RYJ, Ngarnkuekool W, et al. A compre-hensive review of home sleep monitoring technologies:smart-phone apps,smartwatches,and smart mattresses[J]. Sensors, 2025, 25(6):1771.
DOI URL |
| [17] |
Mohamed M, Mohamed N, Kim JG. Advancements in wearable EEG technology for improved home-based sleep monitoring and assessment:a review[J]. Biosensors, 2023, 13(12):1019.
DOI URL |
| [18] |
Ahmadzadeh S, Luo JK, Wiffen R. Review on biomedical sen-sors,technologies and algorithms for diagnosis of sleep disor-dered breathing:comprehensive survey[J]. IEEE Rev Biomed Eng, 2022, 15:4-22.
DOI URL |
| [19] | 姚建国. 数字病理临床应用现状及前景展望[J]. 四川大学学报(医学版), 2021, 52(2):156-161. |
| Yao JG. Digital pathology: current status and prospects of clinical application[J]. J Sichuan Univ Med Sci Ed, 2021, 52(2):156-161. | |
| [20] | 郑迎春. 胸部数字X线摄影联合肿瘤标志物检验在肺癌筛查中的应用价值[J]. 影像研究与医学应用, 2025, 9(16):141-143. |
| Zheng YC. Application value of digital chest radiography combined with tumor marker detection in lung cancer scree-ning[J]. Imag Res & Med Appli, 2025, 9(16):141-143. | |
| [21] |
Im H, Castro CM, Shao HL, et al. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone[J]. Proc Natl Acad Sci USA, 2015, 112(18):5613-5618.
DOI PMID |
| [22] | Qi YJ, Su GH, You C, et al. Radiomics in breast cancer:cur-rent advances and future directions[J]. Cell Rep Med, 2024, 5(9):101719. |
| [23] |
Cay G, Sada YH, Dehghan Rouzi M, et al. Harnessing physical activity monitoring and digital biomarkers of frailty from pendant based wearables to predict chemotherapy resilience in veterans with cancer[J]. Sci Rep, 2024, 14(1):2612.
DOI PMID |
| [24] |
Beg S, Handa M, Shukla R, et al. Wearable smart devices in cancer diagnosis and remote clinical trial monitoring:tran-sforming the healthcare applications[J]. Drug Discov Today, 2022, 27(10):103314.
DOI URL |
| [25] |
Basch E, Schrag D, Henson S, et al. Effect of electronic sym-ptom monitoring on patient-reported outcomes among patients with metastatic cancer:a randomized clinical trial[J]. JAMA, 2022, 327(24):2413-2422.
DOI URL |
| [26] |
Rocque GB, Franks JA, Deng LQ, et al. Remote symptom mo-nitoring with electronic patient-reported outcomes in clinical cancer populations[J]. JAMA Netw Open, 2025, 8(5):e259852.
DOI URL |
| [27] | Low CA, Bartel C, Durica K, et al. Consumer wearable device measures of gait cadence and activity fragmentation as predi-ctors of survival among patients undergoing chemotherapy[J]. JCO Clin Cancer Inform, 2025, 9:e2500111. |
| [28] |
Yang TY, Kuo PY, Huang YR, et al. Deep-learning approach to predict survival outcomes using wearable actigraphy device among end-stage cancer patients[J]. Front Public Health, 2021, 9:730150.
DOI URL |
| [29] |
Scott SE, Thompson MJ. “Notification!you may have cancer.”could smartphones and wearables help detect cancer early?[J]. JMIR Cancer, 2024, 10:e52577.
DOI URL |
| [30] |
Zhong XY, Deng JQ, Lu P, et al. Wearable device for axillary lymph node screening in breast cancer based on infrared thermography and artificial intelligence[J]. Breast Cancer Res, 2025, 27(1):104.
DOI PMID |
| [31] |
Macias Alonso AK, Hirt J, Woelfle T, et al. Definitions of digital biomarkers:a systematic mapping of the biomedical literature[J]. BMJ Health Care Inform, 2024, 31(1):e100914.
DOI URL |
| [32] | Ortiz BL, Gupta V, Kumar R, et al. Data preprocessing techni-ques for AI and machine learning readiness:scoping review of wearable sensor data in cancer care[J]. JMIR Mhealth Uheal-th, 2024, 12:e59587. |
| [33] | Birla M, Rajan, Roy PG, et al. Integrating artificial intellige-nce-driven wearable technology in oncology decision-making:a narrative review[J]. Oncology, 2025, 103(1):69-82. |
| [34] |
彭燕霞, 高云飞, 雍敬敬, 等. 社区老年人对数字健康技术焦虑的现状及护理对策分析[J]. 中华护理杂志, 2023, 58(11):1345-1351.
DOI URL |
| Peng YX, Gao YF, Yong JJ, et al. Current status of commu-nity-dwelling older adults’ anxiety toward digital health tech-nologies and analysis of nursing countermeasures[J]. Chin J Nurs, 2023, 58(11):1345-1351. | |
| [35] |
孙可盈, 贺方园, 张柔, 等. 数字健康技术在妊娠期糖尿病患者营养管理中的应用进展[J]. 中华护理杂志, 2025, 60(14):1694-1699.
DOI URL |
| Sun KY, He FY, Zhang R, et al. Application progress of digi-tal health technologies in nutritional management of patients with gestational diabetes mellitus[J]. Chin J Nurs, 2025, 60(14):1694-1699. |
| [1] | 冯丽, 郭沛然, 程蓉, 熊楚琴, 张志霞. 基于时机理论的运动康复方案在慢性阻塞性肺疾病患者中的应用效果评价[J]. 中华护理杂志, 2026, 61(8): 1013-1020. |
| [2] | 刘幸, 范文祥, 周庭戌, 商临萍. 慢性阻塞性肺疾病患者戒烟行为促进与障碍因素的质性研究[J]. 中华护理杂志, 2026, 61(8): 1021-1027. |
| [3] | 孙雪英, 李君, 李玉峰, 崔学芬, 李东盼, 程兆晶, 李响, 孙秀杰. 慢性阻塞性肺疾病患者健康管理旅程地图的研究[J]. 中华护理杂志, 2026, 61(8): 1028-1035. |
| [4] | 于云龙, 李双, 罗瑶, 张遂乐, 彭粤铭. 慢性阻塞性肺疾病急性加重期患者症状负担与疾病感知的相关性研究[J]. 中华护理杂志, 2026, 61(8): 1036-1042. |
| [5] | 李英, 闵玉娣, 罗葳, 高轩, 赵晟楠. 老年牙列缺损患者结构化健康教育方案的构建及应用研究[J]. 中华护理杂志, 2026, 61(8): 1043-1050. |
| [6] | 张莹, 杜若飞, 杨惠敏, 杜亚婷. 非霍奇金淋巴瘤患者化疗期衰弱轨迹的潜在类别及影响因素研究[J]. 中华护理杂志, 2026, 61(8): 1051-1058. |
| [7] | 李珊, 邵梦琪, 邱晨, 苏清清, 高远. 4 907例老年髋部骨折患者术后并发症发生现状及影响因素研究[J]. 中华护理杂志, 2026, 61(8): 1059-1065. |
| [8] | 谢海燕, 曹淼, 闫睿, 刘思第, 薛荣娜, 谢丹. 10白塞病患者生活质量影响因素的混合研究[J]. 中华护理杂志, 2026, 61(8): 1066-1073. |
| [9] | 舒适, 朱杉, 余艮珍, 张萍, 周晨曦, 彭维, 王珍. 特发性中枢性性早熟患儿患病体验与需求的质性研究[J]. 中华护理杂志, 2026, 61(8): 1074-1079. |
| [10] | 杜倩, 胡恒瑜, 李珍, 曹静文, 刘星歌, 刘林莉. 作业疗法联合职业康复对结直肠癌患者术后重返工作岗位的效果研究[J]. 中华护理杂志, 2026, 61(8): 1080-1087. |
| [11] | 谭远俏, 刘伟宸, 王露秀, 张乐, 衡清漪, 凌瑛. 肺癌患者化疗前后社会支持变化对身体活动的影响研究[J]. 中华护理杂志, 2026, 61(8): 1088-1094. |
| [12] | 杜依娟, 曹严菲, 许倩, 程志润, 陈田, 张凤. 生育文化对孕妇孕期体力活动决策的影响研究及护理启示[J]. 中华护理杂志, 2026, 61(8): 1095-1100. |
| [13] | 许国萍, 胡欢婷, 李丽, 金静芬, 蒋佳奖, 任英. 膝关节假体周围感染患者就医决策历程的质性研究[J]. 中华护理杂志, 2026, 61(8): 1101-1106. |
| [14] | 刘素玲, 蒋伟红, 李晓艳, 唐晓敏. 1例完全型Shone综合征合并重度肺动脉高压患儿的康复护理[J]. 中华护理杂志, 2026, 61(8): 1107-1111. |
| [15] | 陈建芬, 朱慧娣. 1例胃癌根治术后患者发生复杂肠瘘的护理[J]. 中华护理杂志, 2026, 61(8): 1112-1116. |
| 阅读次数 | ||||||
|
全文 |
|
|||||
|
摘要 |
|
|||||
