To summarize the nursing experience of a rare case of pseudo-hypertriglyceridemia caused by non-glycerol kinase deficiency combined with severe acute pancreatitis. The key nursing points include：establishing a multidisciplinary case management team；collaborating with pharmacists to create an ICU database of glycerol-containing medications to standardize drug management；closely monitoring disease progression to enable early detection and standardized management of pseudo-hypertriglyceridemia；implementing refined nursing care for double filtration plasmapheresis nursing，observe and handle parameter settings, alarms, and complications；performing early identification and standardized management of intra-abdominal hemorrhage. After the aforementioned intervention，the patient’s abdominal pain symptoms were alleviated and renal function gradually recovered. After 25 days of treatment，the patient’s condition stabilized and he was discharged from the hospital upon recovery.
