Objective To explore the effect of nursing interventions based on the Interaction Model of Client Health Behavior(IMCHB) in cardiac rehabilitation of patients with coronary heart disease after stent implantation. Methods The convenience sampling method was adopted to select 40 patients with coronary heart disease after stent implantation in the cardiovascular department of a tertiary A hospital in Wuhan from April to July 2022 as the experimental group,and this group received the cardiac rehabilitation guidance and nursing intervention based on the interactive model of health behavior. A total of 40 patients with coronary heart disease who were hospitalized from December 2021 to March 2022 after stent implantation were selected as the control group,and this group received the routine cardiac rehabilitation guidance and nursing. The 6-minute walking distance,low density lipoprotein levels,medication compliance scores,self-efficacy scores and quality of life scores before and after intervention were compared between the 2 groups. Results A total of 75 patients completed the study, with 38 in the experimental group and 37 in the control group. After the intervention,the 6 minutes walking distance of the experimental group was(526.79±40.70),which was higher than(469.41±55.82) in the control group. The level of low density lipoprotein was(1.49±0.39) in the experimental group,which was lower than (1.77±0.49) in the control group,and the differences were statistically significant(P<0.05). The score of medication compliance in experimental group was(7.29±0.35) points,which was higher than(6.33±0.37) points in the control group. The score of self-efficacy was(7.04±0.65),which was higher than(5.98±0.74) in the control group. The quality of life score was (64.47±6.25),which was higher than(55.43±5.94) in the control group,and the differences were statistically significant(P<0.001). Conclusion The cardiac rehabilitation guidance and nursing intervention based on the IMCHB can improve patients’ subjective initiative,so as to improve patients’ medication compliance,improve patients’ sense of self-efficacy and quality of life,promote patients’ cardiac rehabilitation.