Objective To summarize the best available evidence of discharge follow-up of patients after knee arthroplasty,and to provide reference for clinical practice. Methods We searched National Guideline Clearinghouse,National Institute for Health and Care Excellence,the Scottish Intercollegiate Guidelines Network,Canadian Medical Association Infobase(CMA),Guidelines International Network(GIN),and National Health And Medical Research Council(NHMRC),Registered Nurses’Association of Ontario(RNAO),Cochrane Library,JBI Library,CINAHL,Uptodate,BMJ best practice,Embase,Pubmed,CNKI,Wanfang Data,China Biology Medicine disc(CBM) and the VIP Database(VIP) for all evidence of discharge follow-up of patients who underwent knee arthroplasty,including guidelines,systematic reviews,evidence summary,recommended practices,and original studies. Results A total of 9 articles were selected in the literature,including 1 clinical decision,2 guidelines,3 systematic reviews,1 randomized controlled trial,2 expert consensuses. Finally 17 items of best evidence were summarized and categorized into 5 dimensions of recommendations,including follow-up time and method,physical assessment,drug management,discharge rehabilitation,and health education. Conclusion This study summarized the best evidence of discharge follow-up after knee arthroplasty,and nurses should receive relevant training to apply the best evidence to clinical practice. When applying the best evidence,medical staff should consider the patient’s wishes and specific clinical conditions,and combine professional judgment to form an effective and feasible follow-up strategy to improve the quality of nursing quality.