Objective To systematically evaluate the effects of oral care using colostrum in preterm infants.Methods We searched databases including PubMed,EMBASE,Cochrane Library,Web of Science,CINAHL,CBM,CNKI and Wanfang. We included all randomized controlled trials and clinical controlled trials which using colostrum in preterm infants’ oral care. The quality of articles was appraised by the Cochrane Handbook(5.1.0),and RevMan 5.3 software was used to analyze the data.Results A total of 10 studies were included. The results showed that oral care using colostrum reduced the occurrence rate of sepsis[RR=0.54,95%CI(0.36,0.79),P=0.002]and feeding intolerance[RR=0.59,95%CI(0.40,0.87),P=0.008],shorten the time to reach full enteral feeding[MD=-3.70,95%CI(-6.38,-1.02),P=0.007]. At the same time,the detection rate of pathogenic microorganisms and bacteria in oropharynx decreased,and the level of sIgA in saliva and urine increased. There was no significant difference in occurrence rate of necrotizing enterocolitis[RR=0.78,95%CI(0.43,1.42),P=0.420],time to start enteral nutrition [MD=0.07,95%CI(-0.67,0.81),P=0.850],and time to start oral feeding [MD=-2.45,95%CI(-4.99,0.09),P=0.060].Conclusion Oral care using colostrum can reduce feeding related complications in preterm infants,accelerate feeding process to a certain degree,and enhance immune levels of preemies. More high-quality,large sample studies are needed in order to further explore the effects and the most effective way of oral care using colostrum in preterm infants.