Abstract:

Objective To search，evaluate and summarize the relevant evidence of exercise intervention for patients with multiple myeloma，and provide references for medical staff to guide patients to carry out exercise intervention. Methods The researchers conducted a systematical search in national and international databases，relevant guideline websites and professional society websites for related clinical decisions，recommended practices，guidelines，evidence summaries，expert consensuses，and systematic reviews for exercise intervention in patients with multiple myeloma since establishment of databases to May 2023. The quality evaluation，extraction and integration for evidence were conducted independently by 2 researchers，respectively. Results A total of 13 studies，including 2 guidelines，8 systematic reviews，2 expert consensuses and 1 randomized controlled trial，were included. There were 23 pieces of best evidence with 5 dimensions，including the exercise intensity effectiveness，contraindications and indications，exercise pre-intervention evaluation，exercise intervention style and intensity，and exercise intervention management. Conclusion The study summarized the best evidence of exercise intervention for patients with multiple myeloma. It is recommended for health professionals to fully consider the clinical situations to develop more detailed personalized exercise intervention programs based on patients’ own situation.

Key words: Multiple Myeloma, Exercise Intervention, Evidence Summary, Evidence-Based Nursing

摘要：

目的 检索、评价及总结多发性骨髓瘤患者运动干预的相关证据，为医护人员指导患者开展运动干预提供参考。方法 通过计算机系统检索国内外指南网、相关专业学会网站、数据库中关于多发性骨髓瘤患者运动干预的临床决策、推荐实践、指南、证据总结、专家共识、系统评价及随机对照试验。检索时限为建库至2023年5月。由2名研究者独立进行文献质量评价、证据提取及整合。结果 最终纳入13篇文献，其中指南2篇、系统评价8篇、专家共识2篇、随机对照试验1篇。从运动干预的有效性、适应证及禁忌证、运动干预前评估、运动干预的方式和强度、运动干预的管理5个方面总结了23条最佳证据。结论 该研究总结了多发性骨髓瘤患者运动干预的证据，建议医护人员在应用证据时充分考虑临床实际情况，结合患者病情及意愿，为其提供个性化的运动指导。

关键词: 多发性骨髓瘤, 运动干预, 证据总结, 循证护理学