Abstract:

Objective To search，evaluate and integrate relevant evidence of skin care for patients with hematopoietic stem cell transplantation complicated by graft-versus-host disease（GVHD）. Methods Based on the “6S” pyramid model，the evidence was systematically searched in computer decision support systems，websites of guidelines，relevant professional associations and organizations and comprehensive databases，and evidence of skin care for patients with hematopoietic stem cell transplantation complicated by GVHD were screened from the establishment of databases to May 2022，including guidelines，clinical decisions，evidence summaries，systematic reviews，and expert consensuses. The quality evaluation，evidence extraction and integration of the evidence were conducted by 6 research members. Results A total of 15 pieces of literature were included，including 2 clinical decisions，6 guidelines，5 expert consensuses and 2 systematic reviews. 13 pieces of best evidence were summarized from 4 aspects，including multidisciplinary cooperation，skin assessment，nursing interventions and health education. Conclusion This study systematically integrated the relevant evidence of skin care for patients with hematopoietic stem cell transplantation complicated by GVHD，and provided evidence-based references for the development of relevant guidelines and clinical practice standards. When applying the evidence，nurses are recommended to com-prehensively consider the actual clinical situations and patients’ wishes，and select evidences prudently.

Key words: Hematopoietic Stem Cell Transplantation, Graft Versus Host Disease, Skin Care, Evidence-Based Nursing

摘要：

目的 检索、评价并整合国内外关于造血干细胞移植并发移植物抗宿主病患者皮肤护理的相关证据。方法 根据“6S”模型，系统检索国内外计算机决策支持系统、指南网、相关专业学会或机构网站、综合数据库，筛选与造血干细胞移植并发移植物抗宿主病患者皮肤护理相关的文献，包括指南、临床决策、证据总结、系统评价、专家共识，检索时限为建库到2022年5月。由6名研究人员对文献进行质量评价、证据提取及整合。结果 共纳入15篇文献，其中临床决策2篇、指南6篇、专家共识5篇、系统评价2篇。从多学科合作、皮肤评估、护理措施、健康教育4个方面汇总13条最佳证据。结论 该研究系统整合了造血干细胞移植并发移植物抗宿主病患者皮肤护理的相关证据，可为相关指南和临床实践规范的制订提供循证依据。在应用证据时，建议护理人员综合考虑临床实际情况及患者意愿，审慎地选择证据。

关键词: 造血干细胞移植, 移植物抗宿主病, 皮肤护理, 循证护理学