Abstract:

Objective To develop a Symptom Assessment Scale for Donors of Allogeneic-Hematopoietic Stem Cell Transplantation（Allo-HSCT） and its reliability and validity were tested. Methods Based on the literature reviews and semi-structured interviews,the item pool of the scale was developed. The initial scale was formed through 2 rounds of Delphi consultations. Through the pre-survey of 30 donors,the descriptive definition of each item and the reference standard of symptom severity was clarified,and the clinical test scale was formed. A questionnaire survey was conducted on 178 Allo-HSCT donors who admitted to the departments of hematology in 5 tertiary hospitals in Zhejiang Province from January to December 2021 to test the reliability and validity of the scale. Results The Symptom Assessment Scale for Donors of Allo-HSCT included 21 items,and the exploratory factor analysis extracted 7 common factors,and the cumulative variance contribution rate was 67.794%. The content validity index of each item was 0.830~1.000,and the content validity index of the scale was 0.884. Cronbach’s α coefficient,retest reliability and half reliability were 0.811,0.755 and 0.730,respectively. Conclusion The Symptom Assessment Scale for Donors of Allo-HSCT developed in this study has good reliability and validity,and it can be used for symptom assessment of related population.

Key words: Allogeneic-Hematopoietic Stem Cell Transplantation, Donor, Symptom Assessment, Scale Construction, Reliability, Validity, Nursing Care

摘要：

目的 编制适用于异基因造血干细胞移植供者的症状评估量表并检验其信效度。 方法 在文献回顾、半结构式访谈的基础上构建量表条目池;经过2轮专家函询,形成初始版量表;通过对30例供者的预调查,补充各条目的描述性定义及症状严重程度的参考标准。对2021年1月—12月浙江省5所三级甲等医院血液科接收的178例异基因造血干细胞移植供者进行正式调查,检验量表的信效度。 结果 异基因造血干细胞移植供者症状评估量表包括21个条目,探索性因子分析提取7个公因子,累计方差贡献率为67.794%;条目的内容效度指数为0.830~1.000,量表的内容效度指数为0.884;量表总的Cronbach’s α系数为0.811,重测信度为0.755,折半信度为0.730。 结论 异基因造血干细胞移植供者症状评估量表具有良好的信效度,可用于相关人群的症状评估。

关键词: 异基因造血干细胞移植, 供者, 症状评估, 量表编制, 信度, 效度, 护理