Abstract:

Objective To systematically review the risk prediction models for intradialytic hypotension in maintenance hemodialysis patients，with a view to provide references for clinical practice. Methods PubMed，Embase，Web of Science，Cochrane Library，CINAHL，CNKI，VIP，Wanfang and CBM were searched from inception to May 29，2023. 2 reviewers independently screened the literature，extracted information and assessed methodological quality using the Prediction Model Risk of Bias Assessment Tool. Results A total of 20 studies and 25 models were included with the sample size of 68~9 292 cases and the incidence of outcome events of 2.1~51%. Baseline systolic blood pressure，age，ultrafiltration rate，diabetes and dialysis duration were the top 5 predictors of repeated reporting of the models. 20 models reported the area under the curve of ranging from 0.649 to 0.969，and 5 models reported calibration metrics. There were 9 internal validations and 4 combined internal and external validation models. The overall applicability of the 20 studies was good，but all had a high risk of bias，mainly in data analysis. Conclusion Research on risk prediction models for intradialytic hypotension in maintenance hemodialysis patients is still in the developmental stage. Future studies should improve the research design and reporting process，and validation studies of existing models should be carried out to further evaluate the effectiveness and feasibility in clinical practice.

Key words: Hypotension, Hemodialysis, Forecasting Model, Systematic Review, Evidence-Based Nursing

摘要：

目的 系统检索和评价维持性血液透析患者透析中低血压的风险预测模型，以期为临床医护人员选择或开发适合的风险评估工具提供参考。方法 系统检索PubMed、Embase、Web of Science、Cochrane Library、CINAHL、中国知网、维普数据库、万方数据库和中国生物医学文献数据库中相关研究，检索时限为建库至2023年5月29日。由2名研究者独立进行文献筛选、资料提取、并应用预测模型偏倚风险评估工具评估研究的方法学质量。结果 共纳入20项研究，涉及25个模型，样本量为68~9 292例，结局事件发生率为2.1%~51%。基线收缩压、年龄、超滤率、糖尿病和透析时长是模型重复报告的前5名预测变量。20个模型报告了受试者操作特征曲线下面积（0.649~0.969），仅5个模型报告了校准度。9项研究进行内部验证，4项研究内外部验证相结合。20项研究总体适用性较好，但均存在较高的偏倚风险，主要集中在数据分析领域。结论 维持性血液透析患者透析中低血压风险预测模型的研究尚处于发展阶段。未来的研究应完善研究设计和报告流程，并对现有模型进行验证，进一步评估模型在临床实践中的有效性和可行性。

关键词: 低血压, 血液透析, 预测模型, 系统评价, 循证护理学