关键词: 肝移植术, 围手术期, 血液净化, 抗凝管理, 证据总结, 循证护理学

Abstract:

Objective To search and evaluate the relevant evidence of blood purification and anticoagulant management of perioperative liver transplantation patients，and to summarize the best evidence，so as to provide evidence-based evidence for clinical blood purification and anticoagulant management practice. Methods Evidence-based questions were determined. Systematic search was conducted on relevant domestic and foreign databases and websites for clinical decisions，guidelines，evidence summaries，system evaluations，and expert consensuses related to blood purification anticoagulation management. The retrieval period is from the establishment to May 2，2023. Literature screening，quality evaluation and evidence summary were conducted by 2 researchers. Results A total of 17 articles were included，including 2 clinical decisions，3 guidelines，2 evidence summaries，4 systematic evaluations and 6 expert consensuses. 24 pieces of best evidence were summarized from 6 dimensions，including coagulation function evaluation，anticoagulant strategy，mode selection，vascular access，standardized operation implementation points and personnel organization management. Conclusion The best evidence was summarized in the study on perioperative blood purification and anticoagulant management of liver transplantation，which can provide evidence-based basis for clinical medical staff to implement anticoagulant management. However，it is necessary to further carry out evidence-based practice of perioperative blood purification and anticoagulant management of liver transplantation to verify its anticoagulation effect and nursing safety in clinical practice.

Key words: Liver Transplantation, Perioperative Period, Blood Purification, Anticoagulant Management, Evidence Summary, Evidence-Based Nursing