关键词: 中枢神经系统淋巴瘤, 症状群, 核心症状, 纵向研究, 范围综述, 护理

Abstract:

Objective To conduct a scoping review of symptom clusters and core symptoms in patients with central nervous system lymphoma（CNSL） during chemotherapy to provide references for clinical symptom management and practice. Methods Following scoping review guidelines，systematic searches were performed in domestic and international databases and relevant guideline websites from inception to January 20，2026. A total of 2 researchers independently screened the retrieved records，extracted relevant data，and performed analyses. Results A total of 10 studies were included，from which 18 symptom clusters and 7 core symptoms were identified. The most frequent assessment time points across the included studies were after the first，third，and sixth chemotherapy cycles. 12 assessment tools were used，including 8 symptom assessment tools，2 quality-of-life assessment tools，and 2 functional assessment of cancer therapy tools. Based on the frequency of symptom clusters reported in the literature，the top 3 were gastrointestinal symptom cluster，fatigue related side effects symptom cluster，and psychological symptom cluster. The core symptoms that remained stable throughout chemotherapy were fatigue，sleep disturbance，and numbness/tingling. Conclusion The longitudinal research on symptom clusters and core symptoms in CNSL patients receiving chemotherapy is still in its early stages. Most studies concentrated on the induction chemotherapy phase and used generic assessment tools，leading to significant heterogeneity in the types and trajectories of symptom clusters and core symptoms. Future studies should optimize assessment instruments，extend follow-up periods，and further explore the interaction mechanisms between symptom clusters and core symptoms，so as to guide clinical nurses in delivering precise symptom management.

Key words: Central Nervous System Lymphoma, Symptom Clusters, Core Symptoms, Longitudinal Study, Scoping Review, Nursing Care