Objective To explore the effects of positive psychological intervention based on PERMA model of wellbeing on stigma，adaptation to ostomy and quality of life in patients with permanent enterostomy. Methods A total of 83 patients with permanent enterostomy were recruited from October 2022 to September 2023 in a tertiary hospital in Liaoning Province. They were randomly divided into an experimental group and a control group. While the control group received routine nursing，the experimental group received nursing intervention based on PERMA. The intervention lasted 8 weeks，and data were collected before and after the intervention. The scores of the Social Impact Scale（SIS），Ostomy Adjustment Inventory-20（OAI-20） and Stoma Quality of Life（Stoma-QOL） in the 2 groups were compared. Results Experimental group and control group were 40 cases each completed the study. After the intervention,the SIS score of the experimental group was（44.70±9.10），which was significantly lower than （62.15±12.43） of the control group, and the difference between 2 groups was statistically significant（t=-7.163，P<0.001）. The OAI-20 score of the experimental group was（52.28±5.80）, which was significantly higher than（41.53±9.00） of the control group, and the difference between the 2 groups was statistically significant（t=6.349，P<0.001）. The Stoma-QOL score of the experimental group was（54.08±8.29），which was significantly higher than（42.95±9.19）of the control group, and the difference between the 2 groups was statistically significant（t=5.688，P<0.001）. Conclusion Nursing interventions based on PERMA are beneficial in reducing stigma of patients with permanent enterostomy，improving their ostomy adjustment and postoperative quality of life.
