Objective To establish an illness perception intervention program for patients with chronic obstructive pulmonary disease（COPD） and preliminarily analyse its application effect. Methods On the basis of systematic retrieval，a draft of the illness perception intervention program for patients with COPD was formed through content analysis. From May to August 2022，after 2 rounds of expert consultation，the illness perception intervention program for patients with COPD was formed. Patients with COPD who were hospitalized in the respiratory departments of 2 hospitals in Jiangsu Province from December 2022 to January 2023 were selected as the study subjects by convenience sampling method. The experimental group was treated with the illness perception intervention program，while the control group was treated with routine nursing. The effects of the 2 groups were compared by Brief Illness Perception Questionnaire，Modified British Medical Research Council、Brief Illness Perception Questionnaire、Acceptance and Action Questionnaire Ⅱ，COPD Assessment Test，COPD Self-management Scale before and after intervention，and a month after intervention. Results The illness perception intervention program for patients with COPD included 6 intervention topics and 24 specific intervention items. In the 2 rounds of correspondence，the expert group authority coefficient was 0.81，and the Kendall coordination coefficients were 0.19 and 0.16 in the second round（all P<0.001）. In the intervention study，the recruitment rate of patients was 56%；the withdrawal rate was 15%；and the high compliance rate was 80%. Repeated measures analysis of variance showed that there was an interaction effect between the scores of Acceptance and Action Questionnaire Ⅱ of the 2 groups（P<0.05）. The differences in the scores of Brief Illness Perception Questionnaire，COPD Assessment Test，Self-management Scale between the 2 groups were statistically significant in terms of time effect（P<0.05），and the differences in the scores of the Brief Illness Perception Questionnaire and Acceptance and Action Questionnaire Ⅱ between the 2 groups were statistically significant in terms of main effect（P<0.05）. Conclusion The established illness perception intervention program for patients with COPD is scientific，feasible and effective，and it can provide practical references for clinical healthcare workers to promote illness perception and improve negative psychology in patients with COPD.
