Objective To develop a whole course management information system for breast cancer and verify its effect in disease management of breast cancer patients. Methods An integrated service plan and system construction of "screening-diagnosis-treatment-rehabilitation" was developed，and then an information system was developed. The method of historical control was used to conveniently sample 260 cases of breast cancer patients diagnosed in a tertiary A hospital. 130 cases diagnosed from May 1 to December 31，2022 were taken as a test group，and 130 cases diagnosed from May 1 to December 31，2021 were taken as a control group. The test group was managed by the whole course management information system，and the control group was managed by conventional disease management. The relevant indicators of the screening and diagnosis period of patients，the completion rate of treatment，the incidence of treatment related side effects and the cancer care satisfaction of the 2 groups were compared. Results There was a statistically significant difference in puncture waiting time，admission waiting time，and screening admission time between the 2 groups（P<0.05），while there was no statistically significant difference in pathological waiting time（P>0.05）. The treatment completion rate of the test group was higher（P<0.05）. The incidence of lymphedema，chest obstruction and abnormal sensation of upper limbs，subcutaneous hydrops within 6 months after operation and bone marrow suppression，liver function damage，radiation dermatitis and radiation pneumonia in the test group were lower than those in the control group（P<0.05）. The cancer care satisfaction of the test group after surgery and 6 months after surgery were higher than those of the control group（P<0.05）. Conclusion The whole course management information system for breast cancer can optimize the diagnosis and treatment process，raise the diagnosis and treatment efficiency，ensure the treatment completion rate，reduce the treatment complications and improve the cancer care satisfaction.
