Objective To form an expert consensus on parenteral nutrition safety infusion, and standardize the operation process of clinical parenteral nutrition safety infusion,so as to reduce the parenteral nutrition complications. Methods On the basis of the evidence-based method,we searched the high level evidence about the parenteral nutrition safety infusion in databases such as UpToDate,BMJ Best Practice,National Institute for Health and Care Excellence,Guidelines International Network,National Guideline Clearinghouse,Registered Nurses' Association of Ontario,Scottish Intercollegiate Guidelines Network,European Society for Clinical Nutrition and Metabolism,American Society for Parenteral and Enteral Nutrition,Chinese Society for Parenteral and Enteral Nutrition,China Guide Network,Joanna Briggs Institute,China Biomedical Literature Network,VIP,Wanfang,CNKI,PubMed,Web of Science,Scopus,Embase. The retrieval period is from the establishment of the databases to January 2021. Studies were evaluated and collected; relevant recommendations and research results were selected to form the draft of the expert consensus. Experts were invited to complete 2 rounds of Delphi expert consultations and 2 rounds of expert meetings. Each item was revised and improved through 2 rounds of Delphi expert consultations and expert meetings,and the final draft of the consensus was formed. Results The positive coefficient of experts in the 2 rounds of correspondence consultations were 100%; the expert authority coefficients were 81.00% and 89.50% respectively,and the coordination coefficients of expert opinions were 0.13 and 0.15 respectively. Finally,the consensus summarizes the latest evidence on 4 aspects of multidisciplinary team formation,evaluation,operation norms,and complication management. Conclusion The establishment of the consensus can provide a reference for the standardization of safe infusion of parenteral nutrition in clinical practice to ensure patient safety and improve service quality.