Objective To explore the effect of a virtual reality(VR) intervention on the readiness for hospital discharge and early post-discharge self-management ability of patients with colorectal cancer stoma,and to provide references for promoting the smooth transition of patients from hospital to family. Methods A convenience sampling method was used to select patients with colorectal cancer stoma admitted to a tertiary hospital in Zhengzhou from January to October 2024 as the study subjects. 48 patients admitted from June to October 2024 were included in an experimental group, and 48 patients admitted from January to May 2024 were included in a control group. On the basis of routine perioperative health education, the experimental group received virtual reality intervention from the third day after operation to before discharge, while the control group received routine perioperative health education. The patient’s readiness for discharge was evaluated on the day of discharge. The self-management ability and stoma adaptability of the 2 groups were evaluated 3 days after operation, on the day of discharge,1 month and 3 months after discharge,and the incidence of stoma complications was counted. Results 2 cases were lost in the experimental group and the control group, and 46 cases in each group participated in the complete study. The total score of discharge readiness and the scores of each dimension in the experimental group were higher than those in the control group, and the differences were statistically significant(P<0.05). Generalized estimating equation analysis showed that the inter-group effect, time effect and interaction effect of self-management ability and ostomy adaptability in the 2 groups were statistically significant(all P<0.05). There was no significant difference in the incidence of ostomy complications between the 2 groups(P=0.099). Conclusion On the basis of routine perioperative health education,the implementation of virtual reality intervention can effectively improve the discharge readiness and early self-management ability of patients with colorectal cancer stoma,enhance the adaptability of stoma, and have good safety.