Objective To summarize the most robust evidence on application timing and management strategies for chronic wound oxygen therapy and to provide an evidence-based basis for standardizing clinical practice. Methods A systematic literature search of BMJ Best Practice， UpToDate， NICE， SIGN， GIN， NZGG， NGC， RNAO， WOCN， WUWHS， APWCA， IWII， WHS， WI， AWMA， WCET， ESVS， AAWC， Medlive， JBI， Cochrane Library， PubMed， Embase， Web of Science， CNKI， Wanfang and VIP was conducted to collect the literature including clinical decision resources，guidelines，expert consensuses，evidence summaries，systematic reviews，and meta-analyses related to the application timing and management strategies for chronic wound oxygen therapy. The search period spanned from October 13，2018，to October 13，2023. There were 2 researchers who assessed the quality of the included literature，extracted relevant data，and synthesized the evidence. Results In total，we included 28 pieces of literature，consisting of 6 guidelines，4 expert consensus papers，3 evidence summaries，and 15 systematic reviews. From these sources，we distilled 18 pieces of evidence including 7 aspects of indications, contraindications，application timing, assessment，management strategies，effectiveness，and adverse reactions of hyperbaric oxygen therapy；12 pieces of evidence from 6 aspects of indications, application time, assessment, management strategies, effectiveness, and adverse reactions of local oxygen therapy. Conclusion Oxygen therapy can be used as an adjunct therapy for chronic wound management. Clinical practitioners should fully evaluate the scope and timing of the application of oxygen therapy，consider the feasibility，suitability，clinical significance，and effectiveness of evidence based on the specific clinical situations，and apply evidence in combination with patient preferences to promote chronic wound healing.
