Objective To construct a telemedicine-based home care system of palliative care for end-of-life cancer patients,and to evaluate its application effect. Methods The construction of the system was based on the literature research,interview results of the patients and their caregivers,and expert group meeting discussions. From May to August 2023,a total of 88 patients,who were about to be discharged from the palliative care ward of a cancer hospital in Hunan Province,were selected as the study subjects using a convenient sampling method,and then they were divided into an experimental group and a control group according to the order of admission. The experimental group was given home care services based on the system,while the control group was given routine discharge guidance and follow-up visits. The duration of the intervention was 8 weeks. The Chinese version of the Edmonton Symptom Assessment Scale and the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 15 palliative were used to evaluate the symptom burden and quality of life between 2 groups before and after intervention;the Telemedicine Satisfaction Questionnaire was used to evaluate the care satisfaction of the experimental group. Results The system of patient side includes 8 main features,namely personal health record establishment,doctor-patient communication,palliative care knowledge library,medication assistance,smart reporting and monitoring,intelligent Q&A,intelligent follow-up,and intelligent forms. The healthcare professional side includes 7 main functions,namely workbench,case management,follow-up management,warning reminder,popularization push,statistical analysis and user management. A total of 67 patients completed the intervention,with 33 in the experimental group and 34 in the control group. The symptom burden of the experimental group was lower than that of the control group(P<0.05);the quality of life in the experimental group was better than that in the control group(P<0.05);the score of care satisfaction was(59.00±6.66),which indicated a high level of satisfaction. Conclusion The system can reduce the symptom burden and improve the quality of life of end-of-life cancer patients with good practicality