Objective To construct a telemedicine-based home care program for hospice patients that will provide a reference for hospice telemedicine-based home care practices. Methods Using the Supportive Care Model as a theoretical guide,a preliminary telemedicine-based home care program for hospice patients was developed based on literature research combined with qualitative interviews. 2 rounds of expert consultation were conducted in March 2023 to solicit their opinions and revise the proposal to form the final draft. In April 2023,9 patients who were about to be discharged from the palliative care ward of a cancer hospital in Hunan Province,were selected for the preliminary application of the program by the convenience sampling method;the number of cases of adverse events and the Telemedicine Satisfaction Questionnaire were used for the effectiveness of the program. Results A total of 16 experts completed 2 rounds of consultation,and the coefficient of expert authority was 0.928. The effective questionnaire recovery rates of the 2 rounds of consultation were 94.12% and 100%;the expert opinion submission rates were 100% and 25.00%;the coefficients of variation of item scores were 0.05~0.18 and 0~0.16. The coefficients of Kendall harmony in 2 rounds were 0.093 and 0.210(P<0.001). The constructed final program included 4 dimensions of symptom management,daily life care,psycho-spiritual care and social information support,and a total of 17 modules such as pain management,dyspnea management,gastrointestinal symptom management and cough management,which covering 37 specific items. No adverse events occurred during the application and the score of care satisfaction was(60.22±7.41),which indicated a high level of satisfaction. Conclusion The program constructed in this study is scientific,relevant and feasible,and can provide guidance for healthcare professionals in conducting hospice telemedicine-based home care practices.