Objective To construct a structural equation model to analyze the effect of various factors on the quality of life in stroke patients. Methods In this cross-sectional study, a total of 657 stroke patients from 2 tertiary A hospitals in Shanghai were enrolled as investigation subjects via convenience sampling methodology. General information questionnaire，Sense of Coherence Scale-13，Perceived Social Support Scale，Medical Coping Modes Questionnaire，National Institutes of Health Stroke Scale，Self-Esteem Scale and Stroke-Specific Quality of Life were utilized as the investigating tools；Mplus 7.4 was used to construct a structural equation model. Results The average score of quality of life in stroke patients was（178.30±30.30）；neurological status，self-esteem were negatively cor-related with quality of life（P<0.05）；sense of coherence，social support，coping style were positively correlated with quality of life（P<0.05）；sense of coherence，taking a confrontational approach for coping，yielding and neurological status had a direct impact on quality of life（path coefficients were 0.471，0.169、0.135，-0.089，P<0.05）；social sup-port，self-esteem，sense of coherence and neurological status had an indirect impact on quality of life（path coefficients were 0.232，0.108，0.058，-0.058，P<0.001）. Conclusion The quality of life in stroke patients is influenced by multi- ple factors interactively，and sense of coherence is an important factor affecting the quality of life；adopting a confron-tational approach as coping styles，good social support and high self-esteem can improve the level of quality of life.
