Objective This study aims to construct a comprehensive exercise rehabilitation program for elderly patients with cirrhosis and frailty,and to explore its application effect. Methods Through literature research and qualitative research,a comprehensive exercise rehabilitation program was drafted. From November to December 2021,16 experts were consulted,and a comprehensive exercise rehabilitation program for elderly patients with cirrhosis and frailty was formed. From January to June 2022,the convenience sampling was used to select the elderly patients with cirrhosis and frailty in the infection department of a tertiary A hospital in Zhengzhou City as the research subjects. The experimental group was given the comprehensive exercise rehabilitation program on the basis of routine care,while the control group was only given routine care. Liver weakness index,quality of life and adverse events were compared between the 2 groups at 1 and 3 months after the intervention. Results The effective questionnaire recovery rates of the 2 rounds of expert consultations were 85.00% and 94.12%;the expert authority coefficients were 0.823 and 0.833;Kendall harmony coefficients were 0.175 and 0.196(P<0.001). Finally,the comprehensive exercise rehabilitation program included 2 first-level items and 8 second-level items and 24 third-level items. During the application of this program,10 cases dropped,and 58 cases were finally included in the experimental group and the control group respectively. At 1 month after the intervention,the Liver Frailty Index between the 2 groups were statistically significant(P=0.036). At 3 months after intervention,there were significant differences in the Liver Frailty Index and Quality of Life between the 2 groups(P<0.05). No adverse events such as falls and fractures occurred in the 2 groups. Conclusion The comprehensive exercise rehabilitation program constructed in this study is safe and effective for elderly patients with frailty cirrhosis,and it can improve the frailty status and quality of life of elderly patients with cirrhosis.