Objective To carry out evidence-based nursing for the prevention of deep vein thrombosis(DVT) in patients after joint replacement,to formulate review indicators,to analyze the obstacles and promoting factors in the practice of evidence-based nursing,and to formulate action strategies. Methods Based on the Knowledge to Action framework as the theoretical guidance,a total of 24 pieces of evidence for DVT prevention nursing in patients after joint replacement in suitable clinical situations were included;6 examination criteria and 33 examination indexes were formulated;the preventive behavior of nurses was observed on-site with patients as a unit. Furthermore,based on the results of the baseline review,brainstorming was used to analyze the barriers and facilitators in evidence-based practice,and action strategies were formulated. Results Totally 24 pieces of best evidence were included. According to the best evidence,33 examination indexes and 6 examination criteria were established. The clinical compliance rate of the 6 examination criteria ranges from 0% to 100%. Among them,there is room for improvement in health education(0),mechanical prevention(62%),pharmacological prevention(81%) and quality control(21%). Obstacle factors include the lack of tools and nursing processes,lack of knowledge,insufficient attention,busy work,as well as low understanding and low participation. Facilitating factors include strong organizational leadership,medical team cooperation,sufficient equipment,etc. Accordingly,corresponding action strategies have been formulated. Conclusion Based on evidence and clinical experience,we formulated the scientific,appropriate and maneuverable indicators. At present,there is a certain gap between the evidence for the prevention of deep vein thrombosis in patients after joint replacement,and we should fully utilize these facilitating factors,overcome obstacles,implement improving measures,and promote the effective application of evidence.