Objective To retrieve and obtain relevant evidence on the prevention and management of medical adhesive-related skin injury(MARSI) in neonates to guide clinical practice. Methods We searched UpToDate,BMJ Best Practice,Guidelines International Network(GIN),National Guideline Clearinghouse(NGC),Registered Nurses Association of Ontario (RNAO),Medlive,Joanna Briggs Institute (JBI),Cochrane Library,Embase,PubMed,Science Direct,CNKI to collect relevant guidelines,recommended practice,evidence summaries,systematic reviews and expert consensuses published form January 1,2011 to February 18,2021. There were 2 researchers who evaluated the quality of the literature and extracted evidence according to the Australian JBI Centre for Evidence-Based Health Care’s literature evaluation criteria and evidence grading system. Results A total of 10 articles were included,including 2 guidelines,2 evidence summaries,2 systematic reviews,4 expert consensuses. A total of 18 pieces of best evidence were collected,mainly involving 5 aspects of skin assessment,skin protection,employment choices,operation methods,management and training. Conclusion This study summarized the best evidence for the prevention and management of MARSI in neonates. It suggests that the nursing administrators should take the actual situation into consideration to formulate relevant nursing measures in clinical practice. We should solve the problem of MARSI in neonates in a scientific way,which can reduce the occurrence of skin injury and improve nursing quality.