Objective To systematically evaluate the efficacy and safety of plastic wrap for prevention of hypothermia in newborn infants.Methods We searched databases including Cochrane Library,PubMed,Scopus,CINAHL,CBM,Wanfang,VIP,and CNKI. We included all randomized controlled trials which investigated the efficacy and safety of plastic wrap on prevention of hypothermia in newborn infants. Studies were selected according to inclusion and exclusion criteria,data were extracted and study quality was appraised. RevMan 5.2 software was used to analyze the data.Results Sixteen randomized controlled trials which included 2 836 participants were included. The results of meta-analysis showed that hypothermia on admission to the NICU [RR=0.71,95%CI（0.64,0.79）,P<0.01],core body temperature on admission to the NICU[MD=0.60,95%CI（0.47,0.72）,P<0.01],and hyperthermia on admission to the NICU[RR=4.09,95%CI（2.12,7.88）,P<0.01] in the wrapped group were significantly different with those received routine care. There was no significant difference in IVH（grades Ⅲ or Ⅳ）[RR=0.92,95%CI（0.65,1.32）,P=0.66] and death during hospital stay[RR=0.75,95%CI（0.53,1.08）,P=0.12] between the wrapped group and control group.Conclusion Usage of plastic wrap compared with routine care can lead to less hypothermia on admission to NICUs with higher temperature among premature infants（<28 weeks,or ≥28 weeks premature infants）. Caution must be taken to avoid iatrogenic hyperthermia. Plastic wrap cannot decrease the rate of IVH（grades Ⅲ or Ⅳ） and mortality during hospital stay in premature infants.
