Abstract:

Objective To systematically analyze and compare studies related to the intervention effect of topical oxygen therapy on patients with diabetic foot ulcers，and provide references for nursing practice. Methods We searched PubMed，Embase，Web of Science，CENTRAL，CINAHL，Clinical Trial，China Biomedical Literature Database，CNKI，Wanfang Database，and VIP from inception to February 1，2023，to collect studies on the effect of topical oxygen therapy interventions on patients with diabetic foot ulcers. 2 researchers independently screened the literature，and extracted the information，and a meta-analysis of the included literature was performed by RevMan 5.4 software. Results 8 studies with 622 patients were included. Meta-analysis results showed that compared with conventional care，topical oxygen therapy improved the response rate[RR=1.59，95%CI（1.16，2.17），P=0.004] and the reduction of diabetic foot ulcer area[MD=28.78，95%CI（14.83，42.73），P<0.001]，and the method did not increase the incidence of adverse events[RR=0.83，95%CI（0.63，1.10），P=0.190]，but the difference was not statistically significant in terms of healing time[MD=9.86，95%CI（-15.39，35.11），P=0.440]. Conclusion Topical oxygen therapy helps to improve the response rate and reduce the ulcer size in patients with diabetic foot ulcers with a better safety profile，but the effect of the intervention on healing time is unclear. Further high-quality randomized controlled trials should be conducted in the future to validate the efficacy of topical oxygen therapy in patients with diabetic foot ulcers.

Key words: Topical Oxygen Therapy, Diabetic Foot, Foot Ulcer, Meta-Analysis, Evidence-Based Nursing

摘要：

目的 系统地分析、比较局部氧疗对糖尿病足溃疡患者干预效果的相关研究，为护理实践提供参考依据。 方法 检索PubMed、Embase、Web of Science、CENTRAL、CINAHL、Clinical Trial、中国生物医学文献数据库、中国知网、万方数据库和维普数据库中有关局部氧疗对糖尿病足溃疡患者干预效果的研究，检索时限为建库至2023年2月1日。由2名研究者独立筛选文献和提取数据，应用RevMan 5.4软件对纳入文献进行Meta分析。 结果 共纳入8项研究，共计622例糖尿病足溃疡患者。Meta分析结果显示，与常规护理相比，局部氧疗可以提高糖尿病足溃疡患者的治疗有效率[RR=1.59，95%CI（1.16，2.17），P=0.004]，提高糖尿病足溃疡面积缩小率[MD=28.78，95%CI（14.83，42.73），P<0.001]，且该方法未增加不良事件发生率[RR=0.83，95%CI（0.63，1.10），P=0.190]，但在愈合时间[MD=9.86，95%CI（-15.39， 35.11），P=0.440]方面差异无统计学意义。 结论 局部氧疗有助于提高糖尿病足溃疡患者的治疗有效率，缩小溃疡面积，安全性较好，但对愈合时间的干预效果尚不明确。未来应开展高质量随机对照试验以进一步验证局部氧疗对糖尿病足溃疡患者的疗效。

关键词: 局部氧疗, 糖尿病足, 足溃疡, Meta分析, 循证护理学