Abstract:

Objective To systematically evaluate the intervention effects of compression sleeves on breast cancer-related lymphedema（BCRL），thereby providing an evidence-based support for its clinical practice. Methods The randomized controlled trials（RCTs） regarding the effect of compression sleeves intervention in BCRL patients were systematically retrieved from databases including CNKI，Wanfang Database，VIP，CBM，PubMed，and Embase from inception to September 1，2025. Totally 2 researchers independently screened the literature and extracted data according to inclusion and exclusion criteria. The quality of the included studies was assessed using the Cochrane Risk of Bias Tool for Randomized Controlled Trials（version 5.1.0）. Meta-analysis was performed using RevMan 5.4 software，and the evidence was synthesized and graded with the GRADE（grading of recommendations assessment，development，and evaluation） approach. Results A total of 11 studies involving 418 BCRL patients were included. The meta-analysis showed that compression sleeves significantly reduced the volume or circumference of the affected limb in patients with BCRL[SMD=-0.39，95%CI（-0.59，-0.19），P<0.001]，and improved flexion of shoulder[SMD=-2.09， 95%CI（-3.85，-0.33），P=0.020]. However，the effects on abduction of shoulder[SMD=-0.87，95%CI（-2.14，0.40）， P=0.180]，subjective symptoms[SMD=0.19，95%CI（-0.03，0.35），P=0.670]，and quality of life[MD=0.36，95%CI （-8.68，9.40），P=0.940] were not significant. GRADE evidence grading showed the certainty of evidence for limb volume or circumference as an outcome was moderate，while that for all other outcomes was low. Conclusion Compression sleeves can effectively reduce the volume or circumference of the affected limb in patients with BCRL，and this evidence is highly certain. They also improve shoulder anterior flexion function. Further research is needed to confirm its effects on abduction of shoulder，subjective symptoms，and quality of life.

Key words: Compression Sleeves, Breast Neoplasms, Lymphedema, Meta-Analysis, Evidence-Based Nursing

摘要：

目的 系统评价压力袖套对乳腺癌相关淋巴水肿患者的干预效果，为其临床应用提供循证依据。方法 系统检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase等数据库，纳入有关压力袖套对乳腺癌相关淋巴水肿患者干预效果的随机对照试验，检索时限为建库至2025年9月1日，由2名研究者按照文献的纳入与排除标准独立筛选文献，并提取数据，使用Cochrane 5.1.0手册评估文献质量，应用RevMan 5.4软件进行Meta分析，采用推荐分级的评估、制订与评价系统进行证据的汇总与分级。结果 纳入11项研究，共计418例乳腺癌相关淋巴水肿患者。Meta分析结果显示，压力袖套可以减少乳腺癌相关淋巴水肿患者患肢的体积或周径[SMD=-0.39， 95%CI（-0.59，-0.19），P<0.001]，可使患肢肩关节前屈活动度增加[SMD=-2.09，95%CI（-3.85，-0.33），P=0.020]，患肢肩关节外展活动度[SMD=-0.87，95%CI（-2.14，0.40），P=0.180]、主观症状[SMD=0.19，95%CI（-0.03，0.35），P=0.670]和生活质量的干预效果[MD=0.36，95%CI（-8.68，9.40），P=0.940]与对照组相比，差异无统计学意义。患肢体积或周径结局指标的证据质量为中等质量，其余为低质量。结论 压力袖套能有效地减少乳腺癌相关淋巴水肿患者患肢的体积或周径且证据确信。压力袖套还可改善患者的肩关节前屈功能，但在改善肩关节外展功能、主观症状和生活质量方面的效果仍需要进一步研究。

关键词: 压力袖套, 乳腺肿瘤, 淋巴水肿, Meta分析, 循证护理学