关键词: 造血干细胞移植, 疲乏, 证据总结, 循证护理学

Abstract:

Objective To retrieve，evaluate and summarize domestic and foreign available evidence on the management of fatigue in patients with hematopoietic stem cell transplant（HSCT），so as to provide references for clinical evidence-based practice. Methods We systematically searched domestic and foreign computer decision support systems，guideline websites，databases，and relevant society websites for evidence on the management of fatigue in patients with HSCT，including guidelines，clinical decision-making，recommended practices，evidence summaries，systematic reviews，and expert consensuses published from the establishment of the databases or websites to February 10，2022. There were 2 researchers who evaluated the quality of the included literature independently，and combined the professional judgement with information extraction. Results A total of 24 pieces of literature were eligible for inclusion，including 4 clinical guidelines，2 evidence summaries，1 expert consensus and 17 systematic reviews. There were 24 pieces of best evidence with 8 dimensions being summarized，namely assessment，exercise management，psychosocial interventions，health education，nutritional therapy，complementary and alternative therapies，rational drug use，and shared decision-making and multidisciplinary collaboration. Conclusion Nursing staff should pay attention to the management of fatigue in patients with HSCT，and manage patients’ fatigue in a standardized，effective，and safe way according to characteristics of clinical environment and patients’ preferences，so as to improve their prognosis and quality of life.

Key words: Hematopoietic Stem Cell Transplantation, Fatigue, Evidence Summary, Evidence-Based Nursing